Table 2.
Metabolic alterations driven by doxorubicin treatment in ovo determined on the lipidomics platform.
| Metabolite | Pathway | Beta | p-Value |
|---|---|---|---|
| DAG(16:0/22:5) | Diacylglycerol Ester | −1.21 | 2.10 × 10−2 |
| DAG(16:0/22:6) | −1.30 | 1.69 × 10−2 | |
| DAG(16:1/22:6) | −1.08 | 3.34 × 10−2 | |
| DAG(18:2/22:5) | −1.04 | 3.54 × 10−2 | |
| DAG(18:2/22:6) | −1.11 | 3.51 × 10−2 | |
| LPE(22:5) | Lysophosphatidylethanolamine Ester | −0.85 | 2.78 × 10−2 |
| MAG(18:1) | Monoacylglycerol Ester | −0.87 | 1.01 × 10−2 |
| PC(14:0/18:1) | Phosphatidylcholine Ester | −0.85 | 3.31 × 10−2 |
| PC(16:0/14:0) | −1.48 | 2.27 × 10−3 | |
| PC(16:0/16:1) | −1.08 | 1.84 × 10−2 | |
| PC(16:0/18:0) | −0.79 | 3.42 × 10−2 | |
| PC(16:0/20:1) | −1.00 | 1.10 × 10−2 | |
| PC(16:0/20:2) | −1.07 | 7.59 × 10−3 | |
| PC(18:0/14:0) | −1.07 | 1.15 × 10−2 | |
| PC(18:0/16:1) | −1.09 | 3.49 × 10−2 | |
| PC(18:0/18:1) | −1.01 | 2.50 × 10−2 | |
| PC(18:1/16:1) | −1.04 | 1.12 × 10−2 | |
| PC(18:1/18:1) | −1.31 | 6.00 × 10−3 | |
| PC(18:1/18:2) | −0.76 | 3.81 × 10−2 | |
| PC(18:1/20:2) | −1.10 | 4.77 × 10−3 | |
| PC(18:1/20:3) | −0.83 | 3.02 × 10−2 | |
| PC(18:1/22:4) | −0.88 | 2.23 × 10−2 | |
| PC(18:1/22:6) | −0.88 | 1.69 × 10−2 | |
| PC(18:2/16:1) | −0.67 | 4.95 × 10−2 | |
| PC(20:0/18:1) | −0.84 | 3.37 × 10−2 | |
| PE(16:0/16:0) | Phosphatidylethanolamine Ester | −0.76 | 3.29 × 10−2 |
| PE(16:0/18:1) | −0.73 | 4.69 × 10−2 | |
| PE(16:0/20:1) | −0.81 | 1.38 × 10−2 | |
| PE(16:0/20:2) | −1.23 | 1.76 × 10−3 | |
| PE(16:0/22:4) | −0.82 | 3.72 × 10−2 | |
| PE(16:0/22:6) | −0.89 | 3.35 × 10−2 | |
| PE(18:0/16:0) | −0.86 | 4.24 × 10−2 | |
| PE(18:0/18:1) | −1.19 | 7.65 × 10−3 | |
| PE(18:0/20:1) | −1.26 | 7.23 × 10−3 | |
| PE(18:0/20:2) | −1.56 | 6.21 × 10−3 | |
| PE(18:0/22:4) | −0.96 | 2.53 × 10−2 | |
| PE(18:0/22:5) | −1.30 | 7.27 × 10−3 | |
| PE(18:0/22:6) | −1.31 | 7.55 × 10−3 | |
| PE(18:1/16:1) | −0.98 | 1.30 × 10−2 | |
| PE(18:1/18:1) | −1.46 | 3.23 × 10−3 | |
| PE(18:1/20:1) | −1.58 | 9.29 × 10−4 | |
| PE(18:1/20:2) | −1.52 | 1.59 × 10−3 | |
| PE(18:1/20:3) | −1.23 | 1.38 × 10−2 | |
| PE(18:1/20:4) | −0.80 | 3.89 × 10−2 | |
| PE(18:1/22:4) | −1.41 | 3.15 × 10−3 | |
| PE(18:1/22:5) | −1.48 | 1.83 × 10−3 | |
| PE(18:1/22:6) | −1.46 | 3.45 × 10−3 | |
| PE(18:2/22:4) | −0.54 | 4.71 × 10−2 | |
| PE(O-18:0/16:0) | −1.19 | 9.90 × 10−3 | |
| PE(P-16:0/20:5) | Phosphatidylethanolamine Plasmalogen | −0.95 | 3.47 × 10−2 |
| PE(P-18:0/16:0) | −1.24 | 6.36 × 10−3 | |
| PE(P-18:0/20:2) | −1.10 | 2.16 × 10−2 | |
| PE(P-18:0/20:5) | −0.94 | 4.43 × 10−2 | |
| PE(P-18:0/22:5) | −0.88 | 3.48 × 10−2 | |
| PE(P-18:0/22:6) | −0.83 | 4.23 × 10−2 | |
| PE(P-18:1/16:0) | −1.34 | 5.72 × 10−3 | |
| PE(P-18:1/18:1) | −0.90 | 2.94 × 10−2 | |
| PE(P-18:1/20:3) | −1.05 | 2.28 × 10−2 | |
| PE(P-18:1/20:4) | −1.01 | 2.45 × 10−2 | |
| PE(P-18:1/22:5) | −1.00 | 3.45 × 10−2 | |
| PE(P-18:1/22:6) | −1.12 | 1.10 × 10−2 | |
| PI(18:0/16:0) | Phosphatidylinositol Ester | −0.82 | 3.65 × 10−2 |
| SM(22:1) | Sphingomyelin | −0.81 | 3.13 × 10−2 |
| SM(24:0) | −1.09 | 1.68 × 10−2 | |
| SM(24:1) | −0.95 | 2.35 × 10−2 | |
| SM(26:0) | −0.98 | 2.57 × 10−2 | |
| SM(26:1) | −1.20 | 3.52 × 10−3 | |
| TAG56:3−FA20:2 | Triacylglycerol Ester | −1.15 | 4.07 × 10−2 |
| TAG56:4−FA22:4 | −1.38 | 3.19 × 10−2 | |
| TAG56:5−FA22:5 | −1.49 | 2.66 × 10−2 | |
| TAG56:6−FA22:6 | −1.45 | 3.16 × 10−2 | |
| TAG58:10−FA22:5 | −1.35 | 3.27 × 10−2 | |
| TAG58:10−FA22:6 | −1.31 | 4.34 × 10−2 | |
| TAG58:6−FA16:0 | −1.36 | 3.69 × 10−2 | |
| TAG58:6−FA18:0 | −1.25 | 4.19 × 10−2 | |
| TAG58:6−FA22:4 | −1.31 | 3.42 × 10−2 | |
| TAG58:6−FA22:5 | −1.43 | 2.79 × 10−2 | |
| TAG58:7−FA16:0 | −1.22 | 3.33 × 10−2 | |
| TAG58:7−FA18:0 | −1.30 | 3.26 × 10−2 | |
| TAG58:7−FA18:1 | −1.33 | 3.09 × 10−2 | |
| TAG58:7−FA18:2 | −1.23 | 3.79 × 10−2 | |
| TAG58:7−FA22:4 | −1.35 | 3.49 × 10−2 | |
| TAG58:7−FA22:5 | −1.47 | 2.35 × 10−2 | |
| TAG58:7−FA22:6 | −1.51 | 2.94 × 10−2 | |
| TAG58:8−FA18:1 | −1.24 | 4.39 × 10−2 | |
| TAG58:8−FA18:2 | −1.37 | 3.27 × 10−2 | |
| TAG58:8−FA22:5 | −1.42 | 2.63 × 10−2 | |
| TAG58:8−FA22:6 | −1.49 | 2.72 × 10−2 | |
| TAG58:9−FA18:2 | −1.35 | 3.24 × 10−2 | |
| TAG58:9−FA22:5 | −1.37 | 4.12 × 10−2 | |
| TAG58:9−FA22:6 | −1.53 | 2.74 × 10−2 | |
| TAG60:10−FA22:5 | −1.79 | 1.11 × 10−2 | |
| TAG60:10−FA22:6 | −1.70 | 1.33 × 10−2 | |
| TAG60:11−FA22:5 | −1.83 | 8.01 × 10−3 | |
| TAG60:11−FA22:6 | −1.78 | 1.14 × 10−2 | |
| TAG60:12−FA22:6 | −1.89 | 8.91 × 10−3 |
DAG—Diacylglycerols; LPE—Lysophosphatidylethanolamine; MAG—Monoacylglycerol; PC—phosphatidylcholine; PE—Phosphatidylethanolamine; PI—Phosphatidylinositol; SM—Sphingomyelin; TAG—Triacylglycerol; FA—Fatty acid chain.