Figure 5.

IL-15 increased NK cell activation and DC maturation triggered by Cetuximab. DCs were co-cultured with NK cells and IIB-BR-G cells opsonized with IC or Cetuximab in the absence (DCs+NK) or presence of 10 ng/mL IL-15 (DCs+NK+IL-15) for 24 h. (A) Expression of CD25 and CD69 in NK cells (n = 4). (B) Concentration of IFN-γ and TNF-α in the co-culture supernatant (n = 3–4). (C) Expression of CD83 and CD86 in DCs (n = 6). Bars with different letters are statistically different, p < 0.05 (ANOVA).