Table 7.
Results from emulsion stability analysis when drug was mixed with Numeta G13E+ (bold font indicate values outside the acceptance criteria) (average ± SD; n = 3).
| Drug | Mix Ratio | Z-Average (nm) | PDI | %PFAT5 | pH | ||
|---|---|---|---|---|---|---|---|
| 0 h | 4 h | 0 h | 4 h | ||||
| Numeta G13E+ | - | 266 ± 1 | 0.12 ± 0.01 | 0.20 ± 0.09 | 0.28 ± 0.08 | 5.50 | 5.50 |
| Paracetamol | 1 + 1 | 236 ± 1 | 0.15 ± 0.02 | 0.24 ± 0.08 | 0.34 ± 0.00 | 5.56 ± 0.04 | 5.54 ± 0.02 |
| 1 + 10 | 240 ± 3 | 0.12 ± 0.01 | 0.24 ± 0.21 | 0.66 ± 0.36 | 5.49 ± 0.03 | 5.50 ± 0.03 | |
| 3 + 2 | 239 ± 1 | 0.12 ± 0.01 | 0.41 ± 0.18 | 0.57 ± 0.41 | 5.50 ± 0.05 | 5.47 ± 0.04 | |
| Vancomycin | 1 + 1 | 241 ± 2 | 0.12 ± 0.04 | 0.49 ± 0.22 | 0.29 ± 0.10 | 5.50 ± 0.02 | 5.49 ± 0.02 |
| 1 + 2 | 238 ± 4 | 0.13 ± 0.02 | 0.16 ± 0.02 | 0.46 ± 0.35 | 5.48 ± 0.01 | 5.47 ± 0.02 | |
| 1 + 5 | 240 ± 1 | 0.12 ± 0.01 | 0.17 ± 0.03 | 0.25 ± 0.05 | 5.52 ± 0.01 | 5.50 ± 0.01 | |
| Fentanyl | 1 + 1 | 241 ± 2 | 0.10 ± 0.00 | 0.16 ± 0.04 | 0.09 ± 0.04 | 5.58 ± 0.03 | 5.59 ± 0.05 |
| 1 + 10 | 240 ± 1 | 0.10 ± 0.01 | 0.13 ± 0.04 | 0.12 ± 0.04 | 5.58 ± 0.10 | 5.54 ± 0.03 | |
| 1 + 20 | 221 ± 1 | 0.12 ± 0.03 | 0.23 ± 0.06 | 0.16 ± 0.03 | 5.53 ± 0.02 | 5.47 ± 0.02 | |