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. 2020 Jul 9;9(7):1655. doi: 10.3390/cells9071655

Figure 6.

Figure 6

Regorafenib promotes dendritic spine formation in primary hippocampal neurons and in the brains of 5x FAD mice. (A–B) Primary hippocampal neurons were transfected with GFP and treated with regorafenib (5 µM) or vehicle (1% DMSO) for 24 h before measuring dendritic spine density (Veh, n = 20; regorafenib, n = 21). (C–H) 5x FAD mice were injected with regorafenib (30 mg/kg, i.p.) or vehicle (2% DMSO + 30 % PEG + 5 % Tween 80) daily for two weeks, and Golgi staining was conducted in the hippocampus CA1 and cortical layer V (n = 4 mice/group). * p < 0.05, ** p < 0.01.