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MPT alterations in human diseases. (A) Effect of ischemia and reperfusion in levels of MPT-regulating factor in insurgence of RCD (purple cells). (B) Schematic representation of the effect of mutations in mitochondrial or nuclear DNA (represented by circular DNA or chromosome, respectively) in human diseases characterized by degeneration of neuronal or muscular tissue. (C) Representation of major alterations in MPT regulators detected in tumor microenvironment.
