Table 1.

Summary of prominent markers, pattern recognition receptors and co-regulatory molecules expressed by cDC1 and cDC2 in mice and men.

Subpopulation	Species	Marker	Level of Detection	Literature
cDC1	Mouse	CD8α (splenic, resident cDC1)	Protein; RNA	[80,86]
		CD1d	Protein	[86]
		CD207; Langerin	Protein; RNA	[35,37,80,82]
		CD24	Protein	[30,35,82]
		CD103+CD11b- migratory cDC1	Protein	[35,42]
	Shared	XCR1	Protein; RNA	[30,33,42,82,86,87,88,89]
		CADM1; TSLC1; NECL-2; IGSF4; SynCAM1;	Protein; RNA	[30,31,33,42,82,86,87,88,89]
		CLEC9A; DNGR-1; CD370	Protein; RNA	[24,28,29,31,33,41,42,46,80,82,87,89,90,91]
		BTLA	Protein; RNA	[30,40,42,86,90]
		CD26	Protein	[29,30,90]
		Sirpα; CD172a negative	Protein	[28,30,92]
		CD11c (human cDC1int)	Protein	[28,30,31,42,80,86,88]
		MHC-II; HLA-DR	Protein	[28,29,30,42,86]
	Human	CD141; BDCA-3	Protein	[28,31,34,82,87,90,92]
		CD103+Sirpα- migratory cDC1	Protein	[42]
cDC2	Mouse	CD4 (lymphoid tissue)	Protein; RNA	[80,93]
		DCIR2 (lymphoid tissue)	Protein; RNA	[55]
		CD103+CD11b+ gut migratory cDC2	Protein	[42]
	Shared	Sirpα; CD172a	Protein	[28,29,30,31,35,42,80,82,86,88,92]
		XCR1 negative	Protein	[30]
		CD11b	Protein; RNA	[28,30,42,80,88]
		CD11c	Protein; RNA	[28,30,31,42,80,86,88]
		MHC-II; HLA-DR	Protein	[28,29,30,42,86]
	Human	CD1c; BDCA-1	Protein; RNA	[28,31,34,80,90,91,92]
		CD1a (skin)	Protein	[28,94]
		CLEC10A	Protein; RNA	[33,45]
		CD163	Protein	[90,92]
		CD1d	Protein; RNA	[33,90]
		FcεRIα	Protein; RNA	[33,80,90]
		CD103+Sirpα+ gut migratory cDC2	Protein	[42]
Subpopulation	Species	TLRs	Level of Detection	Literature
cDC1	Mouse	TLR2	Protein	[86]
		TLR4; CD284	RNA	[80,89]
		TLR11	RNA	[24,46,80,89]
		TLR12	RNA	[24,46,80,86,88,95]
		TLR13	Protein; RNA	[24,46,80,88]
		CD180; RP105	Protein	[86]
	Shared	TLR3	Protein; RNA	[42,80,87,88,89,92,96,97]
		TLR9	Protein; RNA	[24,46,88,89,98]
	Human	TLR6	RNA	[89]
		TLR10; CD290	Protein	[90]
cDC2	Mouse	TLR9	Protein; RNA	[24,46,80,88,98]
		TLR13	Protein; RNA	[24,46,88]
	Shared	TLR1	Protein; RNA	[80,86,89]
		TLR2; CD282	Protein; RNA	[31,80,86,89,92]
		TLR4; CD284	RNA	[80,89]
		TLR5	RNA	[80,89,96,98]
		TLR6	Protein; RNA	[80,86,89]
		TLR7	Protein; RNA	[24,46,80,88,89,91]
		TLR8	Protein; RNA	[80,89,91,92]
		CD180; RP105	Protein	[86,90,92]
	Human	-	-	-
Subpopulation	Species	CLRs	Level of Detection	Literature
cDC1	Mouse	CD207; Langerin	Protein	[35,86]
		CLEC2D	Protein	[86]
		CLEC4A; DCIR; CD367	RNA	[42]
	Shared	DEC205; CD205; Ly75	Protein; RNA	[24,31,35,42,46,55,82,86,88,90]
		CLEC1A	RNA	[42]
		CLEC9A; DNGR-1; CD370	Protein; RNA	[24,28,29,31,33,41,42,46,82,87,89,91]
		CLEC12A; MICL; KLRL1; CLL1	Protein; RNA	[24,46,86,99]
	Human	CD206; MMR (skin)	Protein	[28]
		Dectin-1; CLEC7A; CLECSF12; CD369	Protein	[28]
cDC2	Mouse	Dectin-2; CLEC6A; CLEC4N; CLECSF10	Protein; RNA	[55,88]
		CLEC4a2; DCIR1; CLECSF6	RNA	[55,80,96]
		CLEC4a3; DCIR3	RNA	[55]
		CLEC4a4; DCIR2	Protein; RNA	[24,46,55,86,88]
		DCAR	RNA	[55]
	Shared	CLEC4A; DCIR; CD367 (subtype not defined)	Protein; RNA	[33,42,80,86,96]
		Dectin-1; CLEC7A; CLECSF12; CD369	Protein; RNA	[28,55,86]
		CLEC12A	Protein	[80,100]
		CLEC13A; CD302	RNA	[96]
		CD209 (human gut); CD209a (mouse); DC-SIGN	Protein; RNA	[24,42,46,55,80,89,91]
	Human	CD206; MMR (skin)	Protein	[28,42,90]
		CD207; Langerin	Protein; RNA	[42,91,94]
		CLEC5A (thymic cDC2)	RNA	[31]
		CLEC10A	Protein; RNA	[31,33,42,45,89]
		CLEC11A; CLECSF3 (CD5 low cDC2)	RNA	[91]
		CLEC17A (CD5 high cDC2)	RNA	[91]
Subpopulation	Species	FcγRs	Level of Detection	Literature
cDC1	Mouse	FcγRIII; CD16	Protein; RNA	[56,80,96]
		FcγRIV; CD16.2	Protein	[56]
	Shared	FcγRI; CD64	Protein; RNA	[30,42,56]
		FcγRIIB; CD32b	Protein; RNA	[56,80,86,101]
	Human	FcγRIIA; CD32	RNA	[102]
cDC2	Mouse	FcγRIV; CD16.2	Protein	[56]
		FcγRI; CD64 negative	Protein; RNA	[30,56,80]
	Shared	FcγRIIB; CD32b	Protein; RNA	[33,42,56,80,86,89,102]
		FcγRIII; CD16; human FcγRIIIA	Protein; RNA	[80,101,102]
	Human	FcγRI; CD64	Protein; RNA	[89,101]
		FcγRIIA; CD32	Protein; RNA	[28,31,96,101,102]
Subpopulation	Species	Intracellular Sensors	Level of Detection	Literature
cDC1	Mouse	NLRP3; NALP3; Cryopyrin	Protein	[88]
	Shared
	Human	NLRC5	RNA	[42]
		Caspase-1 low	RNA	[92]
		AIM2	RNA	[92]
		PYCARD	RNA	[92]
cDC2	Mouse	NOD-1; NLRC1	Protein; RNA	[24,46,88]
		CARD9	Protein	[88]
		STING	Protein	[88]
		MDA5	Protein	[88]
		RIG-I	Protein	[88]
		NLRC4	RNA	[24,46]
	Shared	NLRP3; NALP3; Cryopyrin	Protein; RNA	[33,42,88,92]
		Caspase-1 high	Protein; RNA	[42,88,92]
	Human	Caspase-8	RNA	[92]
		NAIP	RNA	[92]
		NLRC4	RNA	[92]
		NLRP1	RNA	[92]
		PYCARD	RNA	[92]
Subpopulation	Species	Co-Regulatory Molecules	Level of Detection	Literature
cDC1	Mouse	-	-	-
	Shared	CD80	Protein	[30,42,55,82,87]
		CD86	Protein; RNA	[31,33,42,55,80,82,87,89,96]
		CD40	Protein; RNA	[30,42,55,89]
		PD-L1; CD274	Protein	[28,30,82,87,89]
	Human	IDO-1	Protein; RNA	[31,33,42,80,89,92]
		IDO-2	RNA	[42]
cDC2	Mouse	-	-	-
	Shared	CD80	Protein	[30,42,55,82,87]
		CD86	Protein; RNA	[30,31,33,42,55,82,87,96]
		CD40	Protein	[30,42,55,89]
		PD-L1; CD274	Protein	[30,80,82,87,89]
	Human	ICOS-L	RNA	[28]
Subpopulation	Species	Other Interesting Molecules	Level of Detection	Literature
cDC1	Mouse	CD36 (Scavenger receptor)	Protein	[86,88]
	Shared	CD135; FLT3	Protein; RNA	[28,80,91]
	Human	TIM-3	Protein	[90]
cDC2	Mouse	Clec12A (marker for cDC2B)	Protein	[80]
		Clec10A (marker for cDC2B)	Protein	[80]
		ESAM (marker for cDC2A or Notch2-dependent cDC2)	Protein	[66,68,80]
	Shared	CD135; FLT3	Protein; RNA	[28,80,91]
	Human	CD36 (marker for DC3; DC2 negative)	RNA	[31,33]
		CD163 (marker for DC3; DC2 negative)	Protein; RNA	[28,33]
		CD5 (marker for DC2; DC3 negative)	Protein; RNA	[90,91]
		CD200R (downregulating DC activity)	Protein	[90]