Table 3.

IPA prediction of upstream regulators that were detected in the livers of mouse models of NASH but not in human NASH cohorts.

	j MCD	k NASH Diet	l NASH Diet + CCl4	n CCl4	m WD + CCl4	Association with Human Fibrosis
SMAD4						NASH
SMAD2						NASH
YAP1						NASH
NOTCH1						NASH
EP300						NASH
NCOR						NASH
p63						NASH, steatosis
SREBP2						Steatosis
CAR						Steatosis
FOS						Steatosis, insulin resistance
PGC1α						Steatosis, insulin resistance
PPARδ						N/A
HIF1α						N/A
MED1						N/A
NCOA1						N/A
SMARCA4						N/A
NCOA2						N/A
FOXO3						N/A
HDAC2						N/A
STAT5b						N/A
STAT6						N/A

Mouse models of NASH using ^j MCD diet (GSE93132), ^k NASH diet (GSE52748), ^l NASH diet coupled with CCl₄ treatment (GSE129525), ^m CCl₄ treatment alone (GSE99010) and ⁿ Western diet coupled with CCl₄ treatment (GSE99010). Abbreviations: transcription factors against decapentaplegic homolog (SMAD), yes-associated protein (YAP), notch receptor 1 (NOTCH1), Histone Acetyltransferase P300 (EP300), nuclear receptor corepressor (NCOR), sterol regulatory element binding protein (SREBP), constitutive androstane receptor (CAR), fos proto-oncogene (FOS), PPARγ coactivator 1 alpha (PGC1α), peroxisome proliferator-activated receptor (PPAR), hypoxia inducible factor 1α (HIF1α), mediator complex subunit 1 (MED1), nuclear receptor coactivator (NCOA), SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily A member 4 (SMARCA4), forkhead protein O (FoxO), histone deacetylase (HDAC), signal transducer and activator of transcription (STAT).