Table 1.

Candidate genes to target peroxisomal activities for anticancer treatment.

Peroxisome Activities	Gene to Target	Tumors to Observe the Anticancer Effects of Targeting Peroxisomal Activities	Ref.
Ether phospholipid biosynthesis	AGPS	breast, prostate cancer and melanoma cell lines, primary human breast tumor tissues	[77]
		glioma and liver cancer cell lines	[89]
	FAR1	chemotherapy refractory lymphoma cell lines and human tumor tissues	[85]
	FAR2	chemotherapy refractory lymphoma cell lines and human tumor tissues	[85]
	GNPAT	chemotherapy refractory lymphoma cell lines and human tumor tissues	[85]
	IDH1	chemotherapy resistant glioma cell lines	[86,87]
		chemotherapy resistant pancreatic cancer cell lines	[88]
Fatty acid β-oxidation	ACOX1	rodent tumors	[59,60]
		liver cancer cell lines, human HCC tissues	[61]
		breast tumor tissues	[62]
	ACOX3	prostate cancer cell lines, prostate tumor tissues	[69]
	DBP	prostate cancer cell lines, prostate tumor tissues	[69]
	MCT2	prostate cancer cell lines, prostate tumor tissues	[70]
Fatty acid α-oxidation	AMACR	prostate cancer cell lines and prostate tumor tissues	[65,66,75,92,93,94,95]
		myxofibrosarcomas tissues	[68]
		colon tumor tissues	[71,72,75]
		gastric tumor tissues	[73]
		breast tumor tissues	[74]
		HCC tumor tissues	[75]
		papillary renal cell carcinoma tissues	[75]
ROS homeostasis	CAT	chemotherapy refractory lymphoma cell lines and human tumor tissues	[85]
Peroxisome biogenesis/degradation	PEX3	chemotherapy refractory lymphoma cell lines and human tumor tissues	[85]
	PEX2	HCC tissues	[99]
	PEX5	HCC cell lines	[102]