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. 2020 Jul 4;9(7):1617. doi: 10.3390/cells9071617

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Localization of cerium oxide nanoparticles in the retinal pigment epithelium. Representative confocal images of retinal cryosections of albino rats immunolabeled with anti-RPE65 (red) in order to detect the retinal pigment epithelium: (A) intravitreally injected with fluorescein-isothiocyanate (FITC-CeO₂) (green), the white arrows indicate the FITC-CeO2 agglomerates, which localize in the retinal pigment epithelium (RPE); (B) Intravitreally injected with standard cerium oxide nanoparticles. The high magnifications show the regions highlighted in the white frames. CeO₂: cerium oxide nanoparticles. FITC-CeO₂: cerium oxide nanoparticles labeled with FITC.