Table 3.

Mean difference in top principal component (PC) scores for targeted metabolites by OGTT time points at early (n = 29), mid-pregnancy (n = 18), and all oral glucose tolerance tests (OGTT) combined (n = 47) ¹.

Fasting		30 min		60 min		120 min
		β (SE)	p Value	β (SE)	p Value	β (SE)	p Value
Early pregnancy
PC1	Ref.	−1.9 (0.7)	0.005	−5.8 (0.7)	<0.001	−9.4 (0.7)	<0.001
PC2	Ref.	−0.9 (0.7)	0.24	−1.8 (0.7)	0.02	−1.4 (0.7)	0.05
Mid-Pregnancy
PC1	Ref.	-	-	−4.7 (1.0)	<0.001	−7.7 (1.0)	<0.001
PC2	Ref.	-	-	0.9 (0.8)	0.29	1.6 (0.8)	0.06
Early and Mid-Pregnancy
PC1	Ref.	−1.2 (0.6)	0.04	−5.4 (0.5)	<0.001	−8.8 (0.5)	<0.001
PC2	Ref.	0.1 (0.6)	0.85	0.8 (0.5)	0.10	0.3 (0.5)	0.60

¹ PC’s were derived from the 65 candidate metabolites measured during the OGTTs for all participants (metabolite levels at fasting and 30, 60, and 120 min post OGTT).