Table 1.
Characteristics, Adherence, and Side Effect Data of Patients With Macrolide-Resistant M. genitalium by Antibiotic Regimen
| Pristinamycin + Doxycycline (n = 73) | Minocycline (n = 35) | |
|---|---|---|
| Median age (IQR), y | 30 (26–34) | 27 (23–33) |
| Time to test of cure, median (IQR), d | 28 (27–32) | 28 (27–35) |
| Gender/orientation | ||
| Female | 24 (33) | 14 (40) |
| Heterosexual men | 21 (29) | 14 (40) |
| Men who have sex with men | 28 (38) | 7 (20) |
| Site of infection | ||
| Cervix/vagina | 21 (28) | 12 (34) |
| Urine/urethral | 44 (59)a | 23 (66) |
| Rectum | 10 (14)a | 0 |
| HIV serostatus | ||
| Negative | 58 (80) | 34 (97) |
| Untested | 12 (16) | 1 (3) |
| Positive | 3 (4) | 0 |
| Previous M. genitalium infection | ||
| Yes | 20 (27) | 9 (26) |
| No | 53 (73) | 26 (74) |
| Symptoms at diagnosis | ||
| No (asymptomatic) | 19 (26) | 5 (14) |
| Yes (symptomatic) | 54 (74) | 30 (86) |
| Clinical diagnosis/indication for test | ||
| Nongonococcal urethritis | 34 (47) | 20 (57) |
| Contact of M. genitalium | 8 (11) | 5 (14)b |
| PID | 1 (1) | 1 (3) |
| Vaginal discharge/abnormal bleeding/dysuria | 13 (18) | 9 (26) |
| Proctitis | 2 (3) | 0 |
| Other | 13 (18) | 0 |
| NGU contact | 2 (3) | 0 |
| PrEP | ||
| Yes | 13 (18) | 2 (6) |
| No | 60 (82) | 33 (94) |
| Pristinamycin (n = 61–63)c | Minocycline (n = 33)d | |
| Adherence | ||
| Took all doses | 55 (90) | 30 (91) |
| Missed 1–5 doses | 6 (10) | 3 (9) |
| Side effects to medication | 38 (60) | 15 (46) |
| Headache | 4 (6) | 5 (14) |
| Diarrhea | 21 (33) | 2 (6) |
| Rash | 1 (2) | 0 |
| Vomiting | 1 (2) | 0 |
| Nausea | 10 (16) | 2 (6) |
| Insomnia | 2 (3) | N/A |
| Fatigue/lethargy | 5 (8) | 2 (6) |
| Reflux/indigestion | N/A | 2 (6) |
| Dizziness/light headedness | 3 (5) | 7 (20) |
| Other | N/A | 1 |
Data are presented as No. (%) unless otherwise indicated.
Abbreviations: IQR, interquartile range; NGU, nongonococcal urethritis; PID, pelvic inflammatory disease; PrEP, pre-exposure prophylaxis.
aTwo patients in the pristinamycin + doxycycline group had both urine and rectal MG infections.
bOne patient with NGU was also a contact of MG.
cAdherence and side effect data were available for 61 and 63 of the 73 patients prescribed pristinamycin + doxycycline, respectively.
dAdherence and side effect data were available for 33 of the 35 patients prescribed minocycline.