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. 2020 Jul 5;7(8):ofaa284. doi: 10.1093/ofid/ofaa284

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© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — CD8⁺ T-cell activation, exhaustion, differentiation, and terminal differentiation in high-risk and low-risk men who have sex with men (MSM) and blood bank donors (BBD). The normalized percentages of T-cell subsets within the total CD4⁺ (A) and CD8⁺ T-cell population (B). The normalized percentages of CD57⁺, CD27⁻CD28⁻, and CD57⁺ expressing cells within CD28⁻ cells within the total CD4⁺ (C) and CD8⁺ T-cell population (D). Men who have sex with men with high-risk sexual behavior (hr-MSM), n = 34; MSM without high-risk sexual behavior (lr-MSM), n = 19; blood bank donors (BBD), n = 26. Significance was assessed on normalized data with multivariable linear regression, corrected for age (*, P < .05; **, P < .01; ***, P < .001; ****, P < .0001; significance after Bonferroni correction in red and bold). Data represent mean ± standard deviation. Some individuals were excluded from analysis due to insufficient cell numbers. SQRT, square root.