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. 2020 Jul 5;7(8):ofaa284. doi: 10.1093/ofid/ofaa284

Table 2.

Multivariable Analyses of Associations Between Sexual Risk Behavior, CMV Serostatus, and Markers of Mitochondrial Respiration and Glycolysis

Markers Variable B (95% CI) P Valuea
Mitochondrial Respiration
 Basal respirationb Group BBD (ref)
lr-MSM −0.20 (−0.88 to 0.48) .56
hr-MSM 0.24 (−0.43 to 0.90) .48
CMV −0.34 (−0.90 to 0.22) .22
 Proton leakb Group BBD (ref)
lr-MSM 0.32 (−0.29 to 0.93) .30
hr-MSM 0.29 (−0.32 to 0.89) .35
CMV −0.18 (−0.68 to 0.33) .49
 Maximal respirationb Group BBD (ref)
lr-MSM −2.06 (−3.42 to 0.69) .004
hr-MSM 0.14 (−1.20 to 1.47) .84
CMV 0.22 (−0.91 to 1.34) .70
 Spare respiratory capacityb Group BBD (ref)
lr-MSM −2.21 (−3.51 to 0.91) .001
hr-MSM 0.06 (−1.21 to 1.34) .91
CMV 0.37 (−0.70 to 1.44) .49
 Nonmitochondrial respirationc Group BBD (ref)
lr-MSM −0.36 (−0.74 to 0.02) .06
hr-MSM 0.24 (−0.17 to 0.66) .24
CMV −0.24 (−0.56 to 0.09) .15
 ATP productionb Group BBD (ref)
lr-MSM −0.20 (−0.87 to 0.46) .54
hr-MSM 0.08 (−0.57 to 0.73) .80
CMV −0.39 (−0.94 to 0.16) .16
Glycolysis
 Nonglycolytic acidificationb Group BBD (ref)
lr-MSM 0.07 (−0.17 to 0.30) .57
hr-MSM −0.03 (−0.28 to 0.22) .81
CMV −0.04 (−0.24 to 0.15) .66
 Glycolysisb Group BBD (ref)
lr-MSM −0.40 (−0.68 to 0.12) .006
hr-MSM −0.36 (−0.66 to 0.07) .02
CMV 0.20 (−0.03 to 0.43) .09
 Glycolytic capacityb Group BBD (ref)
lr-MSM −0.54 (−0.91 to 0.16) .005
hr-MSM −0.41 (−0.81 to 0.02) .04
CMV 0.33 (0.02–0.63) .04
 Glycolytic reserve Group BBD (ref)
lr-MSM −1.02 (−1.87 to 0.17) .02
hr-MSM −0.49 (−1.39 to 0.42) .28
CMV 0.97 (0.27–1.67) .007

Abbreviations: ATP, adenosine triphosphate; B, unstandardized regression coefficient; BBD, blood bank donors; CI, confidence interval; CMV, cytomegalovirus; hr-MSM, men who have sex with men with high-risk sexual behavior; lr-MSM, MSM without high-risk sexual behavior; MSM, men who have sex with men; ref, reference group.

a P of multivariable linear regression corrected for age. Unadjusted P values are given. Bonferroni correction for multiple testing required P < .008 or P < .013 for mitochondrial respiration and glycolysis, respectively (bold).

bLog transformed to obtain normality.

cSquare root transformed to obtain normality.