Table 2.
Markers | Variable | B (95% CI) | P Valuea | |
---|---|---|---|---|
Mitochondrial Respiration | ||||
Basal respirationb | Group | BBD (ref) | ||
lr-MSM | −0.20 (−0.88 to 0.48) | .56 | ||
hr-MSM | 0.24 (−0.43 to 0.90) | .48 | ||
CMV | −0.34 (−0.90 to 0.22) | .22 | ||
Proton leakb | Group | BBD (ref) | ||
lr-MSM | 0.32 (−0.29 to 0.93) | .30 | ||
hr-MSM | 0.29 (−0.32 to 0.89) | .35 | ||
CMV | −0.18 (−0.68 to 0.33) | .49 | ||
Maximal respirationb | Group | BBD (ref) | ||
lr-MSM | −2.06 (−3.42 to 0.69) | .004 | ||
hr-MSM | 0.14 (−1.20 to 1.47) | .84 | ||
CMV | 0.22 (−0.91 to 1.34) | .70 | ||
Spare respiratory capacityb | Group | BBD (ref) | ||
lr-MSM | −2.21 (−3.51 to 0.91) | .001 | ||
hr-MSM | 0.06 (−1.21 to 1.34) | .91 | ||
CMV | 0.37 (−0.70 to 1.44) | .49 | ||
Nonmitochondrial respirationc | Group | BBD (ref) | ||
lr-MSM | −0.36 (−0.74 to 0.02) | .06 | ||
hr-MSM | 0.24 (−0.17 to 0.66) | .24 | ||
CMV | −0.24 (−0.56 to 0.09) | .15 | ||
ATP productionb | Group | BBD (ref) | ||
lr-MSM | −0.20 (−0.87 to 0.46) | .54 | ||
hr-MSM | 0.08 (−0.57 to 0.73) | .80 | ||
CMV | −0.39 (−0.94 to 0.16) | .16 | ||
Glycolysis | ||||
Nonglycolytic acidificationb | Group | BBD (ref) | ||
lr-MSM | 0.07 (−0.17 to 0.30) | .57 | ||
hr-MSM | −0.03 (−0.28 to 0.22) | .81 | ||
CMV | −0.04 (−0.24 to 0.15) | .66 | ||
Glycolysisb | Group | BBD (ref) | ||
lr-MSM | −0.40 (−0.68 to 0.12) | .006 | ||
hr-MSM | −0.36 (−0.66 to 0.07) | .02 | ||
CMV | 0.20 (−0.03 to 0.43) | .09 | ||
Glycolytic capacityb | Group | BBD (ref) | ||
lr-MSM | −0.54 (−0.91 to 0.16) | .005 | ||
hr-MSM | −0.41 (−0.81 to 0.02) | .04 | ||
CMV | 0.33 (0.02–0.63) | .04 | ||
Glycolytic reserve | Group | BBD (ref) | ||
lr-MSM | −1.02 (−1.87 to 0.17) | .02 | ||
hr-MSM | −0.49 (−1.39 to 0.42) | .28 | ||
CMV | 0.97 (0.27–1.67) | .007 |
Abbreviations: ATP, adenosine triphosphate; B, unstandardized regression coefficient; BBD, blood bank donors; CI, confidence interval; CMV, cytomegalovirus; hr-MSM, men who have sex with men with high-risk sexual behavior; lr-MSM, MSM without high-risk sexual behavior; MSM, men who have sex with men; ref, reference group.
a P of multivariable linear regression corrected for age. Unadjusted P values are given. Bonferroni correction for multiple testing required P < .008 or P < .013 for mitochondrial respiration and glycolysis, respectively (bold).
bLog transformed to obtain normality.
cSquare root transformed to obtain normality.