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. 2020 Jul 18;9(7):1725. doi: 10.3390/cells9071725

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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A schematic summary of metabolic pathways (upper panel) determining the tumor suppressive activities (lower panel) for PTEN. See the text for details. (1) PTEN through AMPK induces Krebs cycle and OXFOS. (2) PTEN suppresses glycolysis through PGK1 inhibition. (3) PTEN blocks AKT induced Glut1 translocation and glucose uptake. (4) PTEN blocks mTOR-induced HIF1, PFK1, and glycolysis. (5) PTEN blocks mTOR-induced PKM2 transcription. (6) PTEN decreases PPP flux. (7) PTEN blocks mTOR-induced SREBP transcription factor and lipid synthesis. (8) PTEN reduces pyrimidine synthesis.