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. 2020 Jul 18;9(7):1725. doi: 10.3390/cells9071725

Figure 2.

Figure 2

A schematic summary illustrating mechanisms targeting PTEN and autophagy in cancer cells. See the text for details. (1) The functional interplay between progesterone receptor-B and PTEN, via AKT, modulates autophagy in breast cancer cells. (2) PTEN as a key target of BergaPTEN action in breast cancer cells for the induction of autophagy. (3) DHEA and EPEA through PPARγ-increased expression PTEN, resulting in the inhibition of AKT–mTOR pathways, induction of Bcl-2 phosphorylation, its dissociation from Beclin-1, and autophagy induction.