Table 2. Photophysical and Photochemical Properties, Cytotoxicity Half-Maximal Inhibitory Concentration (IC₅₀) Values (μM, HL60 Cell Line), and Heat Map for the Phototoxicity Indices for Ru(II) Complexes.

		ΦPS
compound	λmax (nm)	water	Opti-MEM	dark IC50, μMa	light IC50, μMa	phototoxicity index, PIb
1	445	0.0011(3)	0.0022(4)	1.0 ± 0.1	1.6 ± 0.2	0.6
1a	435	0.0062(4)	0.0034(5)	0.2 ± 0.1	0.2 ± 0.1	1
2	445	0.0009(3)	0.0008(2)	0.6 ± 0.05	0.5 ± 0.05	1.2
3	450	0.0045(5)	0.0051(3)	2.4 ± 0.2	1.5 ± 0.2	1.5
4	450	0.0024(3)	0.0027(5)	0.8 ± 0.2	0.5 ± 0.1	1.6
5	390	0.0014(3)	0.0005(6)	0.8 ± 0.2c	1.3 ± 0.2	0.6
6	390	0.0009(3)	0.0016(4)	1.0 ± 0.2c	1.4 ± 0.2	0.7
7	415	0.0026(4)	0.0024(5)	0.9 ± 0.1	0.9 ± 0.1	1
8	415	0.0032(6)	0.0028(4)	7.6 ± 0.3	1.5 ± 0.2	5
9	410	n.r.d	n.r.	44.7 ± 1.5	1.6 ± 0.3	28
10	425	n.r.	n.r.	8.5 ± 0.2	0.6 ± 0.2	14
11	415	0.0057(4)	0.0061(6)	116.7 ± 6.6	0.8 ± 0.3	146
12	425	n.r.	n.r.	29.3 ± 1.5	0.5 ± 0.2	59

^aCytotoxicity of compounds evaluated as the average of three measurements. The IC₅₀ value of cisplatin is 3.1 ± 0.3 μM.

^bThe phototoxicity index (PI) is the ratio of the dark and light IC₅₀ values.

^cOnly 60% cell death was achieved at higher concentrations.

^dn.r. = no reaction.