Table 1. Growth Inhibition Percentage (GI %) of in Vitro Subpanel Tumor Cell Lines at Single-Dose (10 μM) Concentration for Compounds 6a, 6b, 6e, 6l, 6n, 6r, 6v, and 6y.

subpanel/cell line		6a	6b	6e	6l	6n	6r	6v	6y
leukemia	CCRF-CEM	a	51					18	46
	K-562	23	85	14	15	19	14	33	53
	MOLT-4	13	51	17		12		18	30
	RPMI-8226		61	20				21	25
	SR	23	64	27	23	36	21	44	28
NSCLSb	A549/ATCC	31	45	18	23	29	17	25	31
	EKVX	13							12
	HOP-62	54	66					20	37
	HOP-92	36	22						11
	NCI-H23	31	35					19	16
	NCI-H322M								22
	NCI-H460	17	65					41	51
	NCI-H522	57	60	39	34	25	41	41	35
colon cancer	COLO 205		17
	HCC-2998	19	12	13
	HCT-116	14	70	17				18	46
	HCT-15		10					37	43
	HT29	28	57	27	27	24	24	15	16
	KM12		40	24				18	22
	SW-620		21					16
CNS cancer	SF-268	31	12	16				25	26
	SF-295		12					10	30
	SF-539	18	15	13			12	18
	SNB-19	17	37	10				18	26
	SNB-75	35	17	12		16	18	17
	U251	50	37					15	33
melanoma	LOX IMVI		38	27				27	37
	MALME-3M		25
	M14		29	14				33	29
	MDA-MB-435		22	19				52	14
	SK-MEL-2	13	27	11				16	20
	SK-MEL-28		15					15	12
	SK-MEL-5		20					16	17
	UACC-257	11	35	20	27	20	23	19	13
	UACC-62		23					28	21
ovarian cancer	IGROV1		17					22	33
	OVCAR-3	12	17					22
	OVCAR-4	41	21	26				22	22
	OVCAR-5		18
	OVCAR-8	41	51					13	20
	NCI/ADR-RES								13
	SK-OV-3	11
renal cancer	786-0	19	20	12
	A498		23	18			10	24
	ACHN		35					17	23
	CAKI-1	21	34	13			11	33	25
	RXF 393	18	45	30				12
	SN12C		21					12	25
	TK-10		29			17
	UO-31							27	23
PCc	PC-3	20	44			10		11	25
	DU-145	16	50	23					19
breast cancer	MCF7	29	28	21			12	30	35
	MDA-MB-231	12	23	11					13
	HS 578T	28		14				27
	BT-549	28	41	29				24	24
	T-47D	36	47	29		15	12	18	29
	MDA-MB-468		33
mean growth, %		16	31	10			2	18	21
sensitive cell lines no.		34	52	30	6	11	12	14	44

^aOnly GI % higher than 10% are shown.

^bNonsmall cell lung cancer.

^cProstate cancer.