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. 2020 Jun 27;12(7):598. doi: 10.3390/pharmaceutics12070598

Table 7.

Analysis of variance (ANOVA) summary and regression analysis of granules dependent responses. CI, confidence interval.

Variables Coefficient Estimate Sum of Squares Standard Error F-Value p-Value 95% CI Low 95% CI High
Mean Granule Size
(Linear Model)
Model - - - 72.53 <0.0001 - -
Intercept 373.16 - 7.50 - - 354.81 391.50
X1 101.84 62,230.35 9.18 123.02 <0.0001 79.37 124.31
X2 43.11 11,150.83 9.18 22.04 0.0033 20.64 65.58
Percent Fines
(Linear Model)
Model - - - 577.35 <0.0001 - -
Intercept 14.42 - 0.2309 - - 13.86 14.99
X1 −9.12 499.05 0.2828 1039.91 <0.0001 −9.81 −8.43
X2 −3.03 55.09 0.2828 114.79 <0.0001 −3.72 −2.34
Bulk Density
(2FI Model)
Model - - - 64.06 0.0002 - -
Intercept 0.3399 - 0.0027 - - 0.3331 0.3467
X1 0.0363 0.0079 0.0032 125.24 <0.0001 0.0280 0.0447
X2 0.0250 0.0038 0.0032 59.29 0.0006 0.0167 0.0333
X1X2 0.0110 0.0005 0.0040 7.65 0.0395 0.0008 0.0212
Angle of Repose
(Linear Model)
Model - - - 42.64 0.0003 - -
Intercept 28.46 - 0.2989 - - 27.72 29.19
X1 −3.21 61.89 0.3661 76.95 0.0001 −4.11 −2.32
X2 −1.06 6.70 0.3661 8.33 0.0278 −1.95 −0.1608

X1 and X2 represent the amount of added water and the PGS amount, respectively; X1X2 is the effect of interaction.