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Non-homologous end-joining repair. Simplified scheme of non-homologous end-joining repair of double strand DNA breaks (gene alterations in OvC in bold) [32]. Protein names: DNA end-binding proteins Ku70/Ku80 (Ku70/Ku80), DNA-dependent protein kinase (DNA-PK), MRE11-RAD50-NBS1 complex (MRN complex), artemis (DCLRE1C), X-ray repair cross complementing-like factor. (XLF), X-ray repair cross complementing 4 (XRCC4), DNA ligase 4 (LIG4) [44].
