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. 2020 Jun 28;12(7):1713. doi: 10.3390/cancers12071713

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Base excision repair. Simplified scheme of base excision repair of small base lesions (gene alternations in OvC in bold, therapeutic interventions considered in OvC therapy marked by red star (PARP inhibitors)) [128]. Protein names: single-strand selective monofunctional uracil DNA glycosylase (SMUG), uracil DNA glycosylase (UNG), 8-oxoguanine DNA glycosylase 1 (OGG1), endonuclease VIII-like (NEIL), MutY DNA glycosylase (MUTYH), apurinic/apyrimidinic endonuclease 1 and 2 (APE1 and 2), poly(ADP-ribose) polymerase 1 (PARP1), DNA polymerase beta, delta and epsilon (POLB, -D, -E), DNA ligase 1 and 3 (LIG1 and 3), X-ray repair cross-complementing 1 (XRCC1), replication factor C (RFC), Flap endonuclease 1 (FEN1), proliferating cell nuclear antigen (PCNA) [44].