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. 2020 Jun 28;12(7):1713. doi: 10.3390/cancers12071713

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Interplay of DNA repair pathways. Simplified scheme of interactions between proteins from distinct DNA repair pathways (genes interacting in OvC in bold). Gene names: breast cancer 1 and 2 (BRCA1 and 2), X-ray repair cross-complementing 1 (XRCC1), Ataxia telangiectasia mutated (ATM), xeroderma pigmentosum complementation group A and C (XPA and C), poly(ADP-ribose) polymerase 1 (PARP1). Protein inhibitors: apurinic/apyrimidinic endonuclease 1 inhibitors (APE1i), poly(ADP-ribose) polymerase inhibitors (PARPi).