TABLE 1.
Obstetric data in unaffected mothers of offspring with inherited bone marrow failure syndromes
| Fanconi anemia |
Dyskeratosis congenita |
Diamond Blackfan anemia |
Shwachman Diamond syndrome |
P value across Syndromes |
|
|---|---|---|---|---|---|
| Number of mothers | 56 | 42 | 47 | 20 | |
| Pregnancy data | |||||
| Age at first pregnancy, median (range) | 25 (15-35) | 22 (17-34) | 23 (15-34) | 22.5 (16-36) | 0.3 |
| Age at last pregnancy, median (range) | 33 (22-47) | 31 (22-43) | 33 (24-47) | 33 (22-42) | 0.1 |
| Gravidity (≤20 weeks), median (range) | 3 (1-8) | 3 (1-10) | 3 (1-8) | 3 (2-6) | 1.0 |
| Parity (>20-week gestation), median (range) | 2 (1-7) | 2.5 (1-10) | 2 (1-6) | 2 (1-5) | 0.4 |
| Pregnancy outcomes | |||||
| Number of pregnancies | 196 | 152 | 161 | 66 | |
| Number of pregnancies with live births (%) | 151 (77%) | 118 (78%) | 122 (76%) | 45 (68%) | 0.5 |
| Number of twin pregnancies (%) | 2 (1%) | 3 (2%) | 5 (3%) | 1 (1.5%) | 0.5 |
| Number of ectopic pregnancies (%) | 4 (2%) | 0 | 4 (2%) | 2 (3%) | 0.3 |
| Number of stillbirths | 1 | 2 | 0 | 0 | 0.4 |
| Number of miscarriages (%) | 24 (12%) | 24 (16%) | 27 (17%) | 13 (20%) | 0.5 |
| Gestational age of miscarriages in weeks, median (range) | 8 (5-12) | 8 (4-19) | 12 (4-20) | 8 (6-15) | 0.1 |
| Number of mothers with miscarriages (%)a | 18 (32%) | 13 (31%) | 13 (28%) | 8 (40%) | 0.8 |
| Number of mothers with recurrent miscarriages (≥2) | 4 | 6 | 9 | 4 | |
| Number of elective abortions (%) | 16 (8%) | 8 (5%) | 8 (5%) | 6 (9%) | 0.5 |
| Number of mothers with elective abortions (%)a | 13 (23%) | 6 (14%) | 7 (15%) | 6 (30%) | 0.2 |
| Obstetric data in relation to affected and unaffected live births | |||||
| Number of pregnancies with affected offspring (%)b | 71 (47%) | 54 (46%) | 53 (43%) | 22 (49%) | 0.9 |
| Number of pregnancies with unaffected offspring (%)b | 80 (53%) | 64 (54%) | 69 (57%) | 23 (51%) | 0.9 |
| Number of pregnancies before 1st affected birth (%)c | 62 (32%) | 53 (35%) | 57 (35%) | 29 (44%) | 0.3 |
| Number of pregnancies after 1st affected birth (%)c | 78 (40%) | 57 (37.5%) | 57 (35%) | 17 (26%) | 0.2 |
| P value for pregnancy before/after 1st affected birth | 0.1 | 0.7 | 1.0 | 0.04 | - |
| Number of abortions before 1st affected birth (%)d | 8 (13%) | 6 (10%) | 7 (12%) | 6 (21%) | 0.7 |
| Number of abortions after 1st affected birth (%)e | 8 (10%) | 2 (4%) | 1 (2%) | 0 | 0.09 |
| P value for abortion before/after 1st affected birth | 0.79 | 0.15 | 0.06 | 0.07 | - |
| Complications in pregnancies resulting in live births | |||||
| Number of pregnancies with complications (%)b | 30 (20%) | 34 (29%) | 34 (28%) | 15 (33%) | 0.2 |
P values across syndromes are global comparing obstetric events among mothers of offspring with the four syndromes.
a
Denominator is the total number of mothers in each group.
b
Denominator is the total number of pregnancies with live births in each group.
c
Denominator is the total number of pregnancies in each group of mothers.
d
Denominator is the number of pregnancies before the 1st affected birth in each group.
e
Denominator is the number of pregnancies after the 1st affected birth in each group.