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. 2020 Aug 4;13(11):100839. doi: 10.1016/j.tranon.2020.100839

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 3 — Cell internalization. (a) ICP-MS analysis of pH 6.2 treatments for Gd concentration in picogram per cell. pHLIP-GdNP treated cells (white) contain 78-fold more intracellular Gd than AGuIX treated cells (gray), after 2 hour incubation at 0.5 mM, in vitro (y-axis is in log scale). (b) Mass cytometry measurements of Gd cellular uptake (upper panel) and Ir DNA intercalator uptake (lower panel) at single cell resolution. The incubation concentration for pHLIP-GdNP is 25-fold lower than for AGuIX due to signal saturation at higher concentrations, indicating far more uptake of the pHLIP-conjugated NPs (0.02 mM pHLIP-GdNP, 0.5 mM AGuIX).