Table 5.

Prediction errors of Cmax and AUC values of the two-step in vitro–in vivo correlations (IVIVC) (linear and polynomial).

Linear IVIVC
	AUC 0→t			Cmax
	EXP	PRED	PE%	EXP	PRED	PE%
Reference	3.765	3.597	4.48	0.225	0.223	0.76
Product A	3.303	3.468	5.00	0.196	0.217	10.33
Product B	3.508	3.581	2.09	0.209	0.215	3.06
Total			3.86			4.71
Polynomial IVIVC
	AUC 0→t			Cmax
	EXP	PRED	PE%	EXP	PRED	PE%
Reference	3.765	3.671	2.52	0.225	0.218	3.07
Product A	3.303	3.505	6.12	0.196	0.211	7.56
Product B	3.508	3.650	4.03	0.209	0.210	0.30
Total			4.22			3.64