Table 6.
Prediction errors of Cmax and AUC values from the one-step in vitro–in vivo correlations.
| tesc IVIVC | ||||||
| AUC 0→t | Cmax | |||||
| EXP | PRED | PE% | EXP | PRED | PE% | |
| Reference | 3.765 | 3.236 | 14.07 | 0.225 | 0.205 | 8.81 |
| Product A | 3.303 | 3.138 | 5.00 | 0.196 | 0.200 | 1.84 |
| Product B | 3.508 | 3.226 | 8.04 | 0.209 | 0.198 | 5.05 |
| Total | 9.04 | 5.24 | ||||
| besc and ESC IVIVC | ||||||
| AUC 0→t | Cmax | |||||
| EXP | PRED | PE% | EXP | PRED | PE% | |
| Reference | 3.765 | 3.773 | 0.20 | 0.225 | 0.228 | 1.71 |
| Product A | 3.303 | 3.638 | 10.13 | 0.196 | 0.219 | 11.61 |
| Product B | 3.508 | 3.757 | 7.09 | 0.209 | 0.218 | 4.45 |
| Total | 5.81 | 5.92 | ||||