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. 2020 Jul 24;36:101658. doi: 10.1016/j.redox.2020.101658

Fig. 1.

Fig. 1

Elevated hepatic PTP1B expression in the chronic plus binge mouse model and alcoholic hepatitis patients. A) Immunoblots of PTP1B and GAPDH expression in liver lysates from wild-type female mice used in the chronic plus binge model (left panel). Pair (n = 5): control diet + maltose gavage, EtOH (n = 6): ethanol diet + ethanol gavage. Each lane represents an independent animal. PTP1B protein level was quantitated and normalized with GAPDH, then expressed as means + SEM (right panel. **p < 0.01 Pair vs. EtOH. (B) Immunostaining of PTP1B in liver sections (n = 4 per group), and (C) hepatic PTPN1 mRNA from healthy subjects (control; Ctrl) and alcoholic hepatitis (AH) patients. Gene expression was determined by qPCR, normalized to B2M mRNA, then expressed as means + SEM (n = 5 for Ctrl and n = 6 for AH). *p < 0.05 Ctrl vs. AH by a two-tailed t-test. A.U.: arbitrary unit. Scale bar: 50 μm.