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. 2020 Jul 21;10(7):1086. doi: 10.3390/biom10071086

Figure 6.

Figure 6

PRU induces cell death by ROS generation through JNK activation. (a) Western blot analysis of JNK, p-JNK, p38, p-p38, ERK, and p-ERK on PRU treated AGS cells. (b) The expression of phosphorylated proteins p-JNK, p-p38, and p-ERK are represented graphically based on their densitometry. (c) The effect of ROS generation was measured by fluorescent intensity detection in AGS cells with and without co-treatment with specific JNK inhibitor SP100125 (10 μM). (d) Cell viability assay performed on PRU treated AGS cells with and without co-treatment with JNK inhibitor SP100125 (10 µM). Values are given as the mean ± standard error of the mean (SEM). * p < 0.05 vs. control, ** p < 0.01 vs. control, *** p < 0.001 vs. control.