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. 2020 Jul 7;10(7):1008. doi: 10.3390/biom10071008

Figure 2.

Figure 2

Substrates of the TIM22 carrier import pathway. Mitochondrial carriers of the mitochondrial carrier family (MCF)/SLC25 family (red), the components of the mitochondrial pyruvate carrier (brown, orange), as well as sideroflexins (blue) are imported into mitochondria via the TIM22 carrier pathway. MCF/SLC25 proteins have a uniform topology with 6 transmembrane segments [4,12,17,19,24]. In contrast, Mpc2/Mpc3 has only 3 TM segments, and Mpc1 has 2 or 3 TM segments [6,7,35,36,37]. The third unique family of metabolite carriers, the sideroflexins, has 5 TM domains with the N-terminus in the intermembrane space (IMS) [8,38,39]. Aside from metabolite carriers, the TIM22 pathway also imports the members of the Tim17 protein family including the translocase components Tim17, Tim22 and Tim23 (green). IMS, intermembrane space; IM, inner membrane.