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. 2020 Jul 11;9(7):1669. doi: 10.3390/cells9071669

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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GCSF treatment upregulated the levels of microRNA-122 in the DRGs of CCI rats on the 1st day after nerve injury. MicroRNA-122 levels in the DRGs of the vehicle-treated CCI rats were significantly decreased compared to those in the DRGs of the sham-operated controls on the 1st day after nerve injury. In contrast, the microRNA levels in the DRGs of the GCSF-treated CCI rats were significantly higher than those in DRGs of the vehicle-treated CCI rats on the 1st day after nerve injury (A). There was no significant difference in microRNA-122 levels between sham-operated, vehicle-treated CCI, and GCSF-treated CCI rats on the 7th day after nerve injury (B). The other 419 screened microRNAs did not show a similar trend. The data are shown as the means ± SEMs (Day 1: n = 3 in each group; Day 7: n = 2 in each group; # p < 0.05: vehicle-treated rats compared to sham-operated rats; * p < 0.05: GCSF-treated CCI rats compared to vehicle-treated CCI rats, unpaired t-test between each group by the default setting of NanoString nSolver software 3.0).