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. 2020 Jul 11;9(7):1669. doi: 10.3390/cells9071669

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Proinflammatory cytokine IL-6 expression in the DRGs of sham-operated rats, vehicle-treated CCI rats, and GCSF-treated CCI rats. The vehicle-treated CCI rats exhibited significantly higher IL-6 levels in the DRGs than the sham-operated rats on the 7th day after nerve injury (B). The GCSF-treated CCI rats exhibited lower IL-6 levels in the DRGs than the vehicle-treated CCI rats on the 1st and 7th days after nerve injury (A,B). However, the difference between the groups did not reach statistical significance (one-way ANOVA, post hoc Tukey’s test or Kruskal–Wallis, post hoc Mann–Whitney rank-sum test, if appropriate; Day 1 and 7: n = 8 per group; # p < 0.05: vehicle-treated rats compared to sham-operated controls).