Table 3.
Time-on-task activation clusters within higher difficulty level blocks.
| Contrast | Anatomical Regions (AAL Atlas) |
Anatomical Regions (Brodmann+ Atlas) | Cluster Size | Peak Z-Value |
p-Value (Cluster) | x, y, z |
|---|---|---|---|---|---|---|
| Controls > Patients | Bilateral cerebellum 6 Bilateral vermis 6 Bilateral calcarine cortex Bilateral lingual gyrus |
Bilateral area 17, 18 23, 30 | 906 | 4.04 | <0.0005 | −2, −74, 0 |
| Superior temporal gyrus (R) Rolandic operculum (R) Superior temporal pole (R) Insula (R) Inferior orbitofrontal gyrus (R) Inferior frontal operculum (R) |
Area 22 (R), 38 (R), 47 (R) | 424 | 4.20 | <0.0005 | 54, 14, −4 | |
| Bilateral medial superior frontal gyrus Bilateral MCC Supplementary motor area (L) Anterior cingulate cortex (L) |
Bilateral area 8, 32 | 260 | 4.15 | <0.0005 | 0, 24, 52 | |
| Inferior frontal operculum (R)Inferior frontal triangularis (R) | Area 46 (R) | 227 | 4.13 | <0.0005 | 46, 14, 34 | |
| Inferior temporal gyrus (R) Crus Cerebelli I (R) Fusiform gyrus (R) Inferior occipital gyrus (R) |
Area 20 (R), 37 (R) | 205 | 4.33 | <0.0005 | 52, −50, −26 | |
| Superior temporal pole (L) Inferior orbitofrontal gyrus (L) Rolandic operculum (L) |
Area 22 (L), 38 (L), 47 (L) | 190 | 4.48 | <0.0005 | −54, 16, −4 | |
| Postcentral gyrus (L) Precentral gyrus (L) |
Area 4 (L), 6 (L) | 166 | 3.91 | 0.001 | −42, −16, 50 | |
| Middle temporal gyrus (L) | Area 22 (L) | 132 | 3.86 | 0.002 | −60, −60, 8 | |
| Middle frontal gyrus (L) Precentral gyrus (L) |
Area 9 (L) | 112 | 4.23 | 0.007 | −44, 10, 40 | |
| Thalamus (R) | Medial dorsal nucleus (R) Ventral anterior nucleus (R) |
106 | 4.25 | 0.013 | 6, −16, 12 | |
| Middle temporal gyrus (L) | Area 22 (L) | 106 | 4.07 | 0.010 | −62, −36, 2 | |
| Inferior occipital gyrus (L) Fusiform gyrus (L) Inferior temporal gyrus (L) |
- | 105 | 3.93 | 0.017 | −46, −70, −12 | |
| Angular gyrus (R) | Area 40 (R) | 96 | 4.02 | 0.024 | 54, −56, 32 | |
| Middle occipital gyrus (L) Superior occipital gyrus (L) |
Area 19 (L) | 87 | 3.99 | 0.037 | −24, −92, 16 | |
| Superior frontal gyrus (L) Middle frontal gyrus (L) |
Area 10 (L) | 71 | 3.99 | 0.017 | −30, 62, 16 | |
| Patients > Controls | No significant findings |
Significant activation differences between groups in the time-on-task within higher difficulty level blocks. Analyses were cluster-corrected (p < 0.05), masked for grey matter, and a minimum cluster size > 20 voxels was used.