Table 2.
Association of Attention-Deficit/Hyperactivity Disorder (ADHD) Polygenic Risk Score (PRS) in Referred Youth With ADHD Diagnosis, Controlling for Age, Sex, and Ancestry Components
| Discovery Threshold | ADHD Spectrum (n = 323) vs. All Others in Clinical Cohort (n = 110) |
||||
|---|---|---|---|---|---|
| OR | 95% CI | Pseudo R2 | Wald χ21 | Permuted p | |
| p < 1.0 × 10−6 | 1.40 | 1.11–1.77 | 1.73 | 8.22 | .0032 |
| p < 1.0 × 10−5 | 1.38 | 1.09–1.74 | 1.52 | 7.23 | .0050 |
| p < 1.0 × 10−4 | 1.26 | 1.01–1.58 | 0.84 | 4.02 | .0397 |
| p < .001 | 1.26 | 1.01–1.58 | 0.85 | 4.06 | .0408 |
| p < .01 | 1.44 | 1.14–1.81 | 2.01 | 9.43 | .0011 |
| p < .05 | 1.31 | 1.05–1.64 | 1.15 | 5.56 | .0165 |
| p < .1 | 1.35 | 1.08–1.69 | 1.45 | 6.98 | .0078 |
| p < .3 | 1.33 | 1.07–1.67 | 1.31 | 6.33 | .0119 |
| p < .5 | 1.39 | 1.11–1.74 | 1.71 | 8.18 | .0034 |
| p < 1 | 1.42 | 1.13–1.78 | 1.90 | 9.07 | .0019 |
Note: Boldface type indicates statistically significant findings after correction. Bonferroni corrected critical value = .008. OR = odds ratio; PRS = Polygenic Risk Score.