Table 4.
Association of Attention-Deficit/Hyperactivity Disorder (ADHD) Polygenic Risk Score (PRS) in Referred Youth With Traits Beyond ADHD, Controlling for Age, Sex, and Ancestry Components
|
ADHD PRS Threshold |
Aggressive Behavior (n = 394) |
Working Memory Indexa (n = 394) |
||||||
|---|---|---|---|---|---|---|---|---|
| b | R2 (%) | F | Permuted p | b | R2 (%) | F | Permuted p | |
| p < 1.0 × 10−6 | 1.35 | 1.90 | 7.66 | .0082 | .94 | .42 | 1.69 | .1982 |
| p < 1.0 × 10−5 | 1.58 | 2.59 | 10.52 | .0019 | .11 | .01 | 0.02 | .8889 |
| p < 1.0 × 10−4 | 1.49 | 2.40 | 9.70 | .0020 | −.09 | .00 | 0.02 | .9003 |
| p < .001 | .94 | .99 | 3.97 | .0471 | −.29 | .04 | 0.18 | .6737 |
| p < .01 | .83 | .77 | 3.05 | .0823 | −1.01 | .54 | 2.18 | .1468 |
| p < .05 | .31 | .11 | 0.42 | .5145 | −1.69 | 1.47 | 5.97 | .0162 |
| p < .1 | .41 | .19 | 0.77 | .3760 | −1.76 | 1.64 | 6.66 | .0113 |
| p < .3 | .44 | .21 | 0.84 | .3573 | −2.17 | 2.47 | 10.10 | .0016 |
| p < .5 | .23 | .06 | 0.24 | .6226 | −2.08 | 2.26 | 9.23 | .0030 |
| p < 1 | .19 | .04 | 0.17 | .6847 | −2.10 | 2.33 | 9.53 | .0025 |
Note: Boldface type indicates statistically significant findings after correction.
a
Also controlled for medication use; Bonferroni corrected critical value = .0083.