Table 2.
Frequency of putative TDF RAMs in genotype A (n = 290) and D (n = 566) HBV sequences downloaded from Hepatitis B Virus Database (HBVdb), https://hbvdb.ibcp.fr/HBVdb/. 840 genotype A and 958 genotype D sequences were downloaded on the 20th of November 2018, and the datasets were filtered to remove highly similar sequences using a 99.5 % similarity threshold, leaving a total of 290 geno-A and 566 geno-D sequences.
| Polymorphism in HBV RT | Frequency in genotype A sequences | Frequency in genotype D sequences |
|---|---|---|
| Y9H | 286/ 290 (98.6 %) | 556/566 (98.2 %) |
| L91I | 290/290 (100 %) | 41/566 (7.2 %) |
| F122Y/L | 8/290 (2.8 %) | 82/566 (14.5 %) |
| H/126Y | 225/290 (77.6 %) | 4/566 (0.7 %) |
| R153W | 228/290 (78.6 %) | 22/566 (3.9 %) |
| V173L | 0/290 (0%) | 4/566 (0.7 %) |
| L180M | 7/290 (2.4 %) | 13/566 (2.3 %) |
| M204I/V | 7/290 (2.4 %) | 25/566 (4.4 %) |
| S223A | 289/290 (99.7 %) | 563/566 (99.5 %) |
| C256S | 279/290 (96.2 %) | 65/566 (11.5 %) |
| D263E | 1/290 (0.3 %) | 111/566 (19.6 %) |
| V278I | 16/290 (5.5 %) | 55/566 (9.7 %) |
| A317S | 4/290 (1.4 %) | 531/566 (93.8 %) |