Figure 3.

The Untranslated Regions (UTRs) of Genes Are Subject to Extensive Regulation by Dynamic Muscle Loading States

(A) Venn diagrams show the extent of overlap in FL-ENST, 3′ UTR, and 5′ UTR gene expression. More genes showed regulation at the 3′ UTR than at the FL-ENST level; however, there was substantial overlap.

(B and C) Heatmaps showing (B) functional pathway enrichment based on gene region (5′ UTR, 3′ UTR, or FL-ENST) and (C) the significance level of different Gene Ontology pathways by transcript type: FL-ENST only versus UTR only versus differential 3′ UTR/5′ UTR regulation only. The ontology enrichment scores are relatively modest after correction for tissue and platform bias. Heatmaps were generated using Metascape (metascape.org). The colors indicate the level of significance, with the darker colors being more significant. The gray boxes are non-significant results.