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. 2020 Jun 27;10(7):407. doi: 10.3390/brainsci10070407

Figure 3.

Figure 3

A schematic representation of the trophic factor pathways used for motor neuron differentiation in this study. Sonic Hedgehog (Shh) pathway in green [17]; Wnt pathway in clear blue [18]; BMP (morphogens bone morphogenetic proteins) pathway in dark blue [19]; transforming growth factor-β (TGF-β) pathway [20]; BDNF (brain-derived neurotrophic factor), IGF-1 (insulin-like growth factor-1), and GDNF (glial cell line-derived neurotrophic factor) pathways in yellow [21,22,23]; Rock inhibitor pathway in purple [24]; FGF2 (fibroblast growth factors) pathway in pink [25]; retinoic acid pathway in red [26]. Red circles indicate the trophic factors used in this study.