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. 2020 Jul 6;12(7):631. doi: 10.3390/pharmaceutics12070631

Figure 3.

Figure 3

MNPs and both MNP-RNases exhibit high biocompatibility. (A) Assessment of the hemolytic effect of MNPs and MNPs-RNase nanobioconjugates. In all cases, hemolysis was below 5%, therefore complying with the ISO 10993 standard. Triton X-100 was used as a positive control. (B) Platelet aggregation for MNPs and MNPs-RNase nanobioconjugates. Platelet aggregation caused by MNPs and MNPs-RNase nanobioconjugates compared to Epinephrine and Thrombin. PBS was used as the negative control. For concentrations of 25 µg/mL and below, MNPs and both MNPs-RNases exhibited a low platelet aggregation tendency. (C) Cytotoxicity of MNPs and MNPs-RNase nanobioconjugates on THP-1 cells and (D) Vero cells.