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. 2020 Jul 6;12(7):631. doi: 10.3390/pharmaceutics12070631

Figure 5.

Figure 5

Minimum intracellular inhibitory concentration against P. aeruginosa in differentiated macrophages of (A) MNPs, (B) MNPs-RNase A and (C) MNPs-RNase 3/1 nanobioconjugates. Differentiated THP-1 cells were exposed at a multiplicity of infection (MOI) of 10:1. Posteriorly, the cells were incubated for 3h, washed and maintained in a fresh medium supplemented with gentamicin. (D) Significant differences between MNPs and MNP-RNase A or MNP-RNase 3/1 were estimated with the two-way ANOVA and Dunnett tests. * p-value < 0.05.