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. 2020 Jun 30;10(7):977. doi: 10.3390/biom10070977

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Analysis of pseudouridine residues in tRNAs and rRNAs by PsiSeq. Normalized PsiSeq signals are shown for selected regions in B. subtilis tRNAs and 23S rRNA. The top row corresponds to the wild-type strain, the middle one for the ΔyjbO mutant, and the bottom one for the ΔyhcT mutant. Positions of known and detected pseudouridine residues are shown by red arrows. Conventional numbering of tRNA positions may not correspond to real position of nucleotide in the sequence due to missing residues and inclusion of 17a, 20a, 20b, and variable loop nucleotides. Identity of tRNA and its anticodon are indicated on the top of each panel. YjbO is involved in pseudouridylation of position 31 (and also 32) in several tRNAs. YhcT is involved in pseudouridylation of 23S rRNA positions 1940, 1944, and 1946 and is the functional equivalent of E. coli RluD.