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. 2020 Jun 30;11(7):658. doi: 10.3390/mi11070658

Table 2.

Summary of all powder-based devices with miniaturized features.

Powder-Based Miniaturized Device Smallest Feature Size 3D-Printing Technique Material Short Description References
Near zero-order release dosage forms (biomedical application) 2.8 mm PBBJ Kollidon SR and hydroxypropylmethyl cellulose PBBJ 3D-printed water-soluble compound enabled a controlled drug released rate based on different ratio of the two polymers [189]
Calcium phosphate powder-binder system for patient-specific implants (biomedical application) 1 mm PBBJ Tetracalcium phosphate, β-tricalcium phosphate and calcium sulfate dihydrate Ceramic bone substitute and scaffold for bone tissue engineering are tested with in vitro cytocompatibility testing [157]
Drug delivery devices (biomedical application) 1 mm Customized PBBJ Paracetamol, lactose, PVP K30, mannitol and colloidal silicon dioxide Oval fast-disintegrating tablet for drug release is 3D-printed with accelerated drug releasing profile [186]
3D-printed fast-disintegrating tablet (biomedical application) 1.4 mm Customized PBBJ Acetaminophen, methylene blue, colloidal silicon dioxide and polyvinylpyrrolidone A fast-disintegrating tablet achieved fast dissolving properties [190]
3D-printed scaffolds with minimum (biomedical application) 330 μm–1 mm PBBJ Stainless steel 316 Various sizes, shapes and lattice structure designs are 3D-printed, evaluated process parameters, dimensional and mechanical properties [171]
3D-printed patient-specific dental implants. (biomedical application) 0.5 mm PBBJ Nickel-based alloy 625 Patient-specific complex metal partial denture framework [181]
3D-printed complex collimator device (electrical and electronic application) 1.5 mm PBBJ B4C–Al composites This highly dense complex collimator is found to be good for neutron scattering [96]
Thick graphene-based electrodes (electrical and electronic application) ~1 mm PBBJ Exfoliated graphene oxide powder Porous graphene-based high-performance supercapacitor is 3D-printed with PBBJ [213]
Graphene hydroxyapatite nanocomposite structures (electrical and electronic application) 4 mm PBBJ Graphene oxide, hydroxyapatite nanocomposite Graphene/HAP nanocomposite 3D-printed cylinder with 125 μm layer thickness proved to have excellent compressive strength [214]
3D electronic applications (electrical and electronic application) ~1 mm PBBJ Gold, silver and copper Conductive paths and other electronic components are 3D-printed for seamless integration with other electrical and electronic functionality [200]
3D printing of fractal antennas (electrical and electronic application) ~2 mm Metal PBBJ Stainless steel The complex inverse Sierpiński tetrahedron fractal antenna proved functional at two WLAN bands with 23% less material used [201]
3D-printed monolithic multi-emitter corona ionizer (electrical and electronic application) 300 μm PBBJ SS 316L Demonstrated the design, manufacture and characterization methods for 3D-printed corona ionizer [52,203]
3D-printed induced orthotropic functional ceramic (electrical and electronic application) ~1–2 mm PBBJ Barium titanate Ceramic-based device for generating piezoelectric response [204]
3D-printed patient-specific ankle-foot orthoses (AFO) (biomedical application) 1.2 mm MJF PA12 The 3D-printed AFO significantly improved the speed and stride length of the stroke patients [108]
3D-printed functional part. (industrial, mechanical applications) 2 mm MJF PA12 Demonstrated the capability of MJF, to printed functional parts with high accuracy [128]
3D-printed scaffold (biomedical application) 40–400 μm SLS Polycaprolactone Effective for cell attachments [126,172]
3D-printed porous Ti–6Al–4V scaffold (biomedical application) 723 μm DMLS Ti–6Al–4V Bone defect repair example of porous Ti–6Al–4V scaffold [177]
3D-printed scaffold (biomedical application 0.5–1.2 μm SLS Ceramic-based material, Bioactivity improvement, better properties [173,174].
3D-printed orally disintegrating printlets (biomedical application) 2 mm SLS Hydroxypropyl methylcellulose and vinylpyrrolidonevinyl acetate copolymer powders Orally disintegrating tablet with tunable drug release profile [192]
3D-printed macrocapsule for cell-based therapies (biomedical application) 0.5 mm–1 mm SLS Alginate-poly-L-lysine Microcapsule which can produce therapeutic proteins [191]
3D-printed electronic circuit carriers (electrical and electronic application) ~1 mm SLS Copper powder Selectively metallize PA12 surface to form electrical interconnects [207,208]
3D-printed thermoplastic polyurethane/graphene cellular structure (electrical and electronic application) ~2 mm SLS Graphene and thermoplastic polyurethane Porous structure which is both electrically conductive and flexible [206]
3D-printed filter (chemical industry applications) 1.5 mm SLS MOF copper (II) benzene-1,3,5-tricarboxylate SLS 3D-printed filters that can filter out precious metal from liquid [198]
3D-printed sandwich material for motorsport applications (aerospace devices) ~1 mm SLS PA12 SLS 3D-printed core structures rival the performance of common aluminum honeycomb sandwich material in term of strength and stiffness [224]
SLS 3D-printed filter for gas separation (chemical industry applications) ~2 mm SLS Brass and polycarbonate/nickel and polyamide/brass, solder and colophony/nickel, solder and colophony SLS 3D-printed filter for separation of concomitant gases [199]
Multi-perforated panels (industrial, and mechanical application) 0.9 mm SLS Polyamide 12 SLS 3D-printed panel for sound damping [225].
AM assisted manufacturing of bipolar plate in fuel cells (electrical and electronic application) 1 mm SLS, SLM Fusion of titanium and gold, stainless steel 3D-printed metal flow field plate gives comparable performance in mass transport compared to conventional machining process [193]
3D-printed complex implant structures (biomedical application) 200 μm SLM Zn 3D-printed, biodegradable Zn based metals cardiovascular stents [178]
3D-printed implant (biomedical application) ~0.26 mm SLM Ti–6Al–4V Biocompatible implant with porous structure for tissue regeneration [175]
3D-printed implant for lower jaw (biomedical application) ~1 mm SLM Titanium Customized implant [176]
3D-printed micro-bore columns for reversed-phase liquid chromatography (biomedical application) 0.9 mm SLM Ti–6Al–4V powder 3D-printed chromatographic column for separation of proteins and peptides [194]
Rectangular waveguide for millimeter-wave application (electrical and electronic application) 0.43 mm SLM Cu-15Sn A mechanically robust waveguide for D, E and F band without post electroplating and assembling [202]
Metal electrodes for electrochemical devices (electrical and electronic application) ~1 mm SLM Stainless steel (316L) 3D-printed electrodes as pseudo capacitor, oxygen evolution catalyst and pH sensor [215]
3D-printed metal electrodes (electrical and electronic application) ~0.4 mm SLM Stainless steel Helical stainless steel electrodes had been coated with IrO2 for pH sensor application [212]
3D-printed multiscale supercapacitor (electrical and electronic application) 150–200 μm SLM Fe–Ni alloy Well-arranged porous structure increases the specific surface area, which leads to a high specific capacitance of device [209]
3D-printed pure copper made for electromagnetic applications (electrical and electronic application) 200 μm LPBF Copper Electrical coil with various shapes and hollow centers is made and testing shows its potential to be used in electric motors, antenna and electromagnetic applications [211]
Ion optics for electric propulsion (aerospace devices) ~1 mm SLM Molybdenum, combinations of molybdenum and titanium 3D-printed grids with sputtering erosion patterns are made and tested as electric propulsion parts [226]
3D-printed FGM turbine disk (aerospace devices) ~1 mm SLM Spherical 316L stainless steel and Cu10Sn copper alloy SLM fabricated 316L/Cu10Sn turbine that has higher hardness than conventional processes [227]
SLM 3D-printed heat transfer devices (devices for other applications) ~0.5 mm SLM Stainless steel, aluminum, Ti–6Al–4V, steel–nickel, Titanium, etc. Customized 3D-printed heat transfer device for cooling applications [228]
3D-printed various lattice heat sinks device (aerospace devices) 0.53 mm SLM Aluminum 6061 3D-printing process improved the efficiency of the heat sink. [229]
3D-printed various fin structures (aerospace devices) 300 µm–1260 µm SLM Aluminum alloy (AlSi10Mg) These 3D-printed fin structures are can be utilized in devices for efficient cooling [230]
3D-printer mesoscale flow reactors (aerospace devices) 1 mm–2 mm SLM Stainless steel Internal flow channel was demonstrated. [231]
3D-printed compact heat switch (aerospace devices) 200 μm–500 μm SLM Ti–6Al–4V Mesoscale hollow internal structures, operates at cryogenic temperature [232]
3D-printed high-temperature aerospace resistojet heat exchanger (aerospace devices) 200 μm–800 μm SLM Stainless steel Design, manufacture and characterization of a high-temperature resistojet for all-electric spacecraft [233]
Manufacturing of glass with various shapes with micro/macro scale resolution (Biomedical, chemical, industrial, and mechanical applications) ~0.5 mm LPBF Soda lime silica glass High level of complexity of small-scale glass structures is 3D-printed opening possibilities for applications in chemistry, biomedical and decorative glass industries [123]
Metallic implants based on laser and electron beam powder-based AM (biomedical application) ~0.3 mm SLM, EBM 316L stainless steel, titanium-6aluminum–4vanadium and cobalt–chromium EBM and SLM 3D printing enable mass customized implant at lower cost compared to conventional molding technique [27]
Marine species tracking tag (biomedical application) 1 mm EBM Titanium A sharp tag with textured surface for easy penetration of marine species‘ skin for tracking purpose [166]
3D-printed disc biocompatibility test (biomedical application) 2 mm EBM Ti–6Al–4V powder Biocompatible disc for fibroblast cell culture [182]
3D-printed mesh for intercellular cell communication and osteoincorporation (biomedical application) ~1 mm EBM Ti–6Al–4V powder Biocompatible mesh for growth of mouse preosteoblast MC3T3-E1 subclone 4 cell line [179]
3D-printed anodized mesh structure (biomedical application) ~0.5 mm EBM Ti–6Al–4V powder Biocompatible mesh for growth of mouse preosteoblast MC3T3-E1 subclone 4 cell line [183]
3D-printed scaffold for cell culture (biomedical application) 0.7 mm EBM Ti–6Al–4V powder Biocompatible foamed structure for growth of mouse preosteoblast MC3T3-E1 subclone 4 cell line [184]
3D-printed scaffold for titanium implant (biomedical application) 0.7 mm EBM Ti–6Al–4V powder Biocompatible scaffold for osseointegration and angiogenesis testing [185]
3D-printed rough and porous dental implants (biomedical application) 500 µm EBM Ti–6Al–4V Dental implants facilities bone ingrowth and strengthens bone bonding [180]
Repair of compressor blade
(aerospace devices)
0.6409 PDMD Inconel 718 Compressor blade repairing using PDMD 3D-printing process [222]