Table 3.
Correlations of sphingolipids with some inflammatory markers and disease activity scores in CD and UC (Spearman’s rank correlation analysis).
| Variables | C16:0-LacCer | C18:0-Cer | C18:1-Cer | C20:0-Cer | C24:0-Cer |
|---|---|---|---|---|---|
| CD group | |||||
| CRP |
R = 0.198 p = 0.25 |
R = 0.136 p = 0.46 |
R = 0.038 p = 0.83 |
R = 0.109 p = 0.55 |
NA |
| ESR |
R = 0.253 p = 0.15 |
R = 0.580 p = 0.0007 |
R = 0.344 p = 0.06 |
R = 0.271 p = 0.15 |
NA |
| Albumin |
R = −0.377 p = 0.036 |
R = −0.481 p = 0.006 |
R = −0.433 p = 0.01 |
R = −0.406 p = 0.023 |
NA |
| WBC |
R = 0.013 p = 0.94 |
R = 0.441 p = 0.01 |
R = −0.02 p = 0.89 |
R = −0.20 p = 0.25 |
NA |
| Hb |
R = −0.451 p = 0.01 |
R = −0.432 p = 0.01 |
R = −0.410 p = 0.02 |
R = −0.507 p = 0.003 |
NA |
| PLT |
R = 0.323 p = 0.07 |
R = 0.626 p = 0.0001 |
R= 0.548 p = 0.001 |
R = 0.099 p = 0.59 |
NA |
| fCal |
R = 0.070 p = 0.69 |
R = 0.293 p = 0.10 |
R = 0.147 p = 0.42 |
R = 0.127 p = 0.49 |
NA |
| PCDAI |
R = 0.252 p = 0.14 |
R = 0.261 p = 0.15 |
R = 0.382 p = 0.03 |
R = 0.009 p = 0.959 |
NA |
| SES-CD |
R = 0.109 p = 0.56 |
R = 0.057 p = 0.75 |
R = 0.09 p = 0.61 |
R = −0.05 p = 0.755 |
NA |
| UC group | |||||
| CRP |
R = 0.442 p = 0.005 |
NA |
R = 0.054 p = 0.74 |
R = 0.099 p = 0.55 |
R = −0.226 p = 0.17 |
| ESR |
R = 0.200 p = 0.23 |
NA |
R = 0.226 p = 0.19 |
R = 0.122 p = 0.48 |
R = −0.127 p = 0.46 |
| Albumin |
R = −0.320 p = 0.049 |
NA |
R = −0.05 p = 0.73 |
R = −0.183 p = 0.27 |
R = 0.217 p = 0.19 |
| WBC |
R = 0.358 p = 0.027 |
NA |
R = 0.054 p = 0.74 |
R = 0.135 p = 0.41 |
R = −0.352 p = 0.03 |
| Hb |
R = −0.165 p = 0.319 |
NA |
R = −0.251 p = 0.12 |
R = −0.029 p = 0.85 |
R = −0.01 p = 0.91 |
| PLT |
R = 0.403 p = 0.012 |
NA |
R = 0.271 p = 0.09 |
R = 0.284 p = 0.08 |
R = −0.166 p = 0.31 |
| fCal |
R = 0.121 p = 0.46 |
NA |
R = 0.077 p = 0.64 |
R = −0.043 p = 0.79 |
R = −0.296 p = 0.07 |
| PUCAI |
R = 0.053 p = 0.74 |
NA |
R = −0.09 p = 0.58 |
R = 0.147 p = 0.37 |
R = −0.341 p = 0.03 |
| Mayo score |
R = −0.13 p = 0.43 |
NA |
R = −0.149 p = 0.37 |
R = −0.05 p = 0.72 |
R = −0.126 p = 0.44 |
UC: ulcerative colitis, CD: Crohn’s disease, PUCAI: pediatric ulcerative colitis activity index, PCDAI: pediatric Crohn’s disease activity index, CRP: C-reactive protein, fCal: fecal calprotectin, ESR: erythrocyte sedimentation rate, Hb: hemoglobin, WBC: white blood cell count, PLT: platelet count, NA: not applicable.