Table 2.
Linear model for mean (s.d.) scores on cognitive function, clinical symptom and functional outcome by group (CCRT and Active control) for baseline, posttreatment and the 3 months follow-up
| CCRT group (n = 196/172/156) | Active control group (n = 115/96/84) | |||||
|---|---|---|---|---|---|---|
| Cognitive outcome | Baseline | Posttreatment | Follow-up | Baseline | Posttreatment | Follow-up |
| MCCB | ||||||
| Speed of processing | ||||||
| Category Fluency Test (animal) | 47.27 (11.09) | 49.31 (10.67) | 49.28 (11) | 46.39 (12.21) | 47.44 (12.61) | 48.47 (12.95) |
| Trail Making Test, Part A | 41.28 (13.50) | 42.79 (12.61) | 43.60 (13.27) | 42.81 (12.70) | 44.22 (13.47) | 47.38 (14.47) |
| Symbol Coding Test | 40.93 (9.28) | 41.75 (8.81) | 43.43 (9.03) | 40.35 (8.95) | 40.04 (9.96) | 43.1 (10.16) |
| Attention/Vigilance | ||||||
| Continuous Performance Test | 44.37 (9.57) | 45.49 (10.36) | 46.96 (10.73) | 42.12 (9.28) | 43.67 (9.37) | 44.86 (11.12) |
| Working memory | ||||||
| Digit Sequencing Test | 45.17 (10.05) | 46.83 (10.39) | 47.26 (9.71) | 43.42 (10.39) | 45.86 (9.73) | 45.42 (11.37) |
| Spatial Span Test | 43.37 (11.63) | 46.81 (10.70) | 46.28 (12.67) | 41.80 (12.70) | 42.27 (11.11) | 43.24 (12.55) |
| Verbal learning | ||||||
| HVLT-R | 42.93 (11.78) | 43.60 (12.07) | 46.95 (12.41) | 42.71 (11.45) | 41.22 (12.61) | 44.9 (13.41) |
| Visual learning | ||||||
| BVMT-R | 43.22 (11.02) | 46.82 (11.44) | 47.40 (11.52) | 44.33 (11.30) | 46.99 (10.87) | 46.35 (11.53) |
| Reasoning and problem solving | ||||||
| Mazes Test | 40.47 (13.15) | 44.05 (11.61) | 43.95 (11.20) | 44.62 (12.65) | 44.78 (12.50) | 45.04 (11.53) |
| Social cognition | ||||||
| MSCEIT | 45.17 (10.79) | 46.8 (10.61) | 44.51 (10.34) | 45.62 (10.82) | 44.14 (10.56) | 43.59 (10.27) |
| MCCB total score | 40.19 (10.62) | 43.20 (10.99) | 43.94 (11.59) | 40.36 (10.09) | 41.36 (10.25) | 43.13 (11.92) |
| Digit Span Testa | 16.29 (4.27) | 17.71 (4.89) | 17.06 (4.35) | 15.36 (5.00) | 15.90 (4.66) | 15.4 (6.06) |
| WCST no. of categoriesa | 2.09 (2.11) | 2.72 (2.20) | 2.49 (2.14) | 2.19 (2.03) | 1.86 (1.98) | 1.85 (1.97) |
| Clinical Symptoms | ||||||
| PANSS total score | 59.77 (12.44) | 57.96 (13.23) | 58.47 (15.08) | 61.62 (13.43) | 60.92 (14.97) | 59.54 (14.73) |
| PANSS positive score | 12.12 (4.76) | 11.86 (4.92) | 11.85 (5.19) | 12.39 (5.08) | 12.51 (5.26) | 11.83 (5.00) |
| PANSS negative score | 17.02 (5.17) | 16.31 (5.22) | 16.94 (6.09) | 17.72 (6.10) | 17.83 (6.34) | 18.02 (6.42) |
| Functional Outcome | ||||||
| UPSA | 41.39 (9.41) | 42.56 (10.84) | 42.80 (10.31) | 38.36 (9.02) | 39.74 (10.78) | 41.84 (10.91) |
| NOSIE | ||||||
| Total positive factor | 78.38 (12.16) | 79.31 (12.81) | 78.40 (11.79) | 73.42 (14.46) | 74.94 (14.39) | 74.77 (12.90) |
| Total negative factor | 24.13 (14.26) | 20.48 (14.01) | 20.66 (14.67) | 27.43 (14.16) | 26.00 (15.78) | 22.24 (13.83) |
| Total score | 182.26 (23.21) | 187.21 (23.55) | 186.22 (23.25) | 173.39 (25.17) | 177.17 (26.69) | 180.48 (24.11) |
| Self-esteem | 27.01 (4.78) | 28.78 (3.71) | 28.64 (3.66) | 26.79 (5.26) | 28.34 (4.12) | 28.51 (3.70) |
CCRT, Computerized Cognitive Remediation Therapy; MCCB, MATRICS Consensus Cognitive Battery; HVLT-R, Hopkins Verbal Learning Test-Revised; BVMT-R, Brief Visuospatial Memory Test-Revised; MSCEIT, Mayer-Salovery-Caruso Emotional Intelligence Test; WCST, Wisconsin Card Sorting Test; PANSS, Positive and Negative Syndrome Scale; UPSA, UCSD Performance-Based Skills Assessment; NOSIE, Nurse's Observation Scale for Inpatient Evaluation.
a
The scales were not included in MCCB.