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. 2020 Aug 4;13(11):100841. doi: 10.1016/j.tranon.2020.100841

Fig. 5.

Fig. 5

FYN promoted gastric cancer cell epithelial-mesenchymal transition through the STAT3 pathway. A. GSEA analysis indicated that FYN was correlated with the STAT3 signaling pathway. B. FYN knockdown inhibited p-STAT3 protein expression as revealed by western blot. C. FYN overexpression elevated p-STAT3 protein expression as revealed by western blot. HO-3867 effectively decreased the levels of VIM, SNAI2, and SNAI1 and increased the expression level of CDH1 as shown by western blot in both SGC-7901 (D) and SNU-216 (E) cell lines. *P < 0.05, **P < 0.01, ***P < 0.001.