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. 2020 Jul 8;12(7):1832. doi: 10.3390/cancers12071832

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Histopathological images of different metaplastic breast carcinoma subtypes. (A). Spindle cell carcinoma entirely composed of neoplastic spindle cells. Inset: Immunohistochemistry showed cytokeratin AE1/AE3 diffuse and intense staining in tumor cells. (B). Squamous cell carcinoma with keratin pearls. (C). Metaplastic carcinoma with mesenchymal (chondroid) differentiation (matrix-producing carcinoma). (D). Immunohistochemistry of case C showed cytokeratin AE1/AE3 expression staining in tumor cells.