Skip to main content
. 2020 Jul 7;12(7):1819. doi: 10.3390/cancers12071819

Figure 3.

Figure 3

X-linked miRNA mapping and key roles in melanoma development and progression. Schematic depiction of miRNA localization on the human X chromosome: miRNAs with a confirmed role in melanoma pathogenesis are shown. Red writing inside boxes indicate miRNAs, target genes (italics) and their downstream oncogenic effects; green writing indicates those with oncosuppressive functions. PAR1 and 2: pseudoautosomal region 1 and 2; p27Kip1: cyclin-dependent kinase inhibitor 1B; ETS-1: ETS proto-oncogene 1; SCD5: Stearoyl-CoA Desaturase 5; SWI-SNF: Switch/Sucrose Non-Fermentable; STAT: Signal Transducer and Activator of Transcription; IL-6 and 10: Interleukin 6 and 10; RUNX3: Runt-related transcription factor 3; IKKα: Inhibitory-KB Kinase α; STAT3: Signal Transducer and Activator of Transcription 3; MEF2C: Myocyte Enhancer Factor 2C; C/EBPβ: CCAAT/enhancer-Binding Protein β; E2F1: E2F transcription factor 1; FOXO1: Forkhead Box protein O1; NF1-A: Nuclear Factor 1 A; Wnt-16: Wnt family member 16; AKT1: AKT serine/threonine kinase 1; CDKN1A: Cyclin-Dependent Kinase Inhibitor 1A; Rbp1-like: Retinol Binding Protein 1-like; Hipk3: Homeodomain-Interacting Protein Kinase 3.