Table 5.
Uni- and multi-variable analysis of PIOS in patients with HCC treated with ICPI.
| Characteristic | Patients (n = 217) | Univariable HR (95% CI) |
p Value | Multivariable HR (95% CI) |
p Value |
|---|---|---|---|---|---|
| ALBI Grade at Cessation, | 47/120/50 | ||||
| 2 vs. 1 | 2.0 (1.1–3.4) | 0.01 * | 1.5 (1.0–3.5) | 0.18 | |
| 3 vs. 1 | 5.1 (2.8–9.3) | <0.001 * | 3.9 (1.9–8.0) | <0.001 * | |
| Age, <65/>65 | 115/102 | 0.53 | |||
| Gender, M/F | 167/50 | 0.26 | |||
| Aetiology, Viral/Non-Viral | 128/89 | 0.94 | |||
|
ECOG PS at Cessation 2–4/0–1 |
51/120 | 1.7 (1.1–2.6) | 0.03 * | ||
|
Baseline AFP,
>400/<400 ng/mL |
81/131 | 0.06 | |||
|
ICPI Regimen,
Monotherapy/Combination |
180/37 | 0.39 | |||
|
Post-ICPI Therapy, Active Treatment/BSC |
78/139 | 0.3 (0.2–0.5) | <0.001 * | 0.3 (0.2–0.5) | <0.001 * |
* indicates statistical significance at p < 0.05.