Table 1.
Baseline characteristics of all patients (N = 1017).
| Patient Characteristics | |
| Age (years), mean (range) | 70.0 (60.0–79.0) |
| Sex, male, N/% | 601/59.1% |
| Weight (kg), mean (range) | 56.0 (48.5–65.4) |
| Pre-Existing Comorbidities | |
| Liver insufficiency, N/% | 49/4.82% |
| Chronic respiratory disorder, N/% | 38/3.74% |
| Chronic heart failure, N/% | 66/6.49% |
| Chronic kidney disease, N/% | 73/7.18% |
| Immunocompromised, N/% | 178/17.5% |
| Infection Site | |
| Catheter related, N/% | 16/1.57% |
| Bone/soft tissue, N/% | 158/15.5% |
| Infectious endocarditis, N/% | 25/2.46% |
| Central nervous system, N/% | 22/2.16% |
| Urinary tract, N/% | 128/12.6% |
| Lung, N/% | 230/22.6% |
| Abdomen, N/% | 364/35.8% |
| Others, N/% | 20/1.97% |
| Illness Severity Score on Day 1, Mean (Range) | |
| APACHE II score | 23.0 (17.0–29.0) |
| SIRS score | 3 (2–4) |
| SOFA score, lung | 2 (1–3) |
| SOFA score, kidney | 2 (0–3) |
| SOFA score, liver | 0 (0–1) |
| SOFA score, cardiovascular | 3 (1–4) |
| SOFA score, coagulopathy | 1 (0–2) |
| SOFA score, central nervous system | 1 (0–2) |
| ISTH overt DIC score | 4.0 (3.0–5.0) |
| Laboratory Data on Day 1, Mean (Range) | |
| White blood cell count (×103/μL) | 11.8 (4.70–19.3) |
| Platelet count (×104/μL) | 111 (56.0–180) |
| Hemoglobin (g/dL) | 10.5 (8.9–12.2) |
| PT ratio | 1.36 (1.20–1.62) |
| Fibrinogen (mg/dL) | 386 (263–544) |
| FDP (μg/mL) | 20.0 (11.0–40.0) |
| D-dimer (μg/mL) | 8.90 (4.30–20.80) |
| Lactate (mmol/L) | 2.80 (1.80–5.04) |
Data are presented as the median and interquartile ranges (25th–75th percentile) or as absolute frequencies with percentages. APACHE, Acute Physiology and Chronic Health Evaluation; SIRS score, Systemic Inflammatory Response Syndrome; SOFA, Sequential Organ Failure Assessment; ISTH overt DIC score, International Society on Thrombosis and Haemostasis overt Disseminated Intravascular Coagulation score; PT, prothrombin time; FDP, fibrin/fibrinogen-degradation product.