Figure 3.

Pretargeting approach: In a first step an Ab with a targeting moiety is injected. Secondly the Ab is allowed to accumulate at tumor site over time. Thirdly a complementary radiolabeled probe is injected and lastly in vivo ligation of the Ab and the radioligand followed by rapid clearance of any excess of the radioligand (figure adapted under a Servier Creative Commons Attribution https://creativecommons.org/licenses/by/3.0/).