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. 2020 Jul 9;12(7):1850. doi: 10.3390/cancers12071850

Figure 2.

Figure 2

The Gas6/Axl signaling promotes the immunosuppressive tumor microenvironment. Axl signaling modulates surface level expression of major histocompatibility complex I (MHC-I) and programmed death ligand-1 (PD-L1) on neoplastic cells. The Gas6/Axl signaling also promotes secretion of immunosuppressive chemokines, including CCL3-5, G-CSF, IL-3, IL-4, IL-6, IL-12_p70, TGFβ, and TNFα. In the context of the tumor immune microenvironment, the Gas6/Axl signaling promotes infiltration of macrophages, monocytes, and myeloid-derived suppressor cells (MDSCs), but decreases infiltration of CD4+ and CD8+ T-cells, and conventional dendritic cells in the tumor.