Table 1.
Axl Signaling Modulates Secretion of Cytokines.
| Changes in Cytokine Secretion upon Axl Inhibition | ||
|---|---|---|
| Increased | Decreased | No Difference |
| Colony stimulating factors | ||
| CSF-1 [84], CSF-2 [77] b, CSF-3 [77,84] b,c | CSF-2 [84] c | |
| Interleukin family | ||
| IL-12p40 [76] a | IL-1a [77] b, IL-3-5 [84] c, IL-6 [77] b, IL-9 [84] c, IL-10 [76] a, IL-12p40 [84] c, IL-12p70 [84] c, IL-13 [84] c, IL-15 [84] c, IL-17 [84] c | IL-1a [84] c, IL-2 [84] c, IL-10 [84] c, LIF [84] c |
| Chemokine family | ||
| CXCL9 [76] a, CXCL10 [76] a, CXCL11 [76] a | CCL-2 [76,84] a,c, CCL-3 [76,77,84] a,b,c, CCL-4 [76,77,84] a,b,c, CCL-5 [76,77,84] a,b,c, CXCL1 [84] c, CXCL2 [84] c, CXCL5 [84] c | CXCL12 [76] a |
| Other family of cytokines | ||
| INF𝛾 [76] a | TGF𝛽 [76] a, TNF𝛼 [77,84] b,c | INF𝛾 [84] c |
Tumor types: a Ovarian and breast cancer models (ID8 and 4T1); b breast cancer cell line (Py8119); c pancreatic adenocarcinoma model, KrasLSL-G12D; Cdkn2afl/fl; Ptf1aCre/+ (KIC).